The synthesis, photochemical and biological properties of new silicon phthalocyanines

Canan Uslan, B. Şebnem Sesalan*

*Bu çalışma için yazışmadan sorumlu yazar

Araştırma sonucu: ???type-name???Makalebilirkişi

37 Atıf (Scopus)

Özet

Bis[(1-methylpyrrolidin-2-yl)methoxy] [phthalocyaninato] silicon (2), bis[2-azepan-1-yl)ethoxy] [phthalocyaninato] silicon (3) and bis[(2,4,6-tris(N,N-dimethylamminomethyl) phenoxy)] [phthalocyaninato] silicon (4) were prepared and they were quaternized with the excess of iodomethane to obtain the compounds 2Q, 3Q and 4Q respectively. The binding of quaternized 2Q, 3Q and 4Q phthalocyanines (pcs) with calf thymus (CT) DNA was investigated by UV-Vis, fluorescence spectrophotometric methods and gel electrophoresis. The quenching effect of all quaternized pcs on the fluorescence intensity of SYBR Gold (SYBR)-DNA complex was determined. The results indicated that novel pcs exhibit efficient DNA binding activity. Photocleavage of CT-DNA in the presence of 2Q, 3Q and 4Q were determined using gel electrophoresis. All the experimental data proved that these pcs might be the candidates as DNA-targetting PDT agents.

Orijinal dilİngilizce
Sayfa (başlangıç-bitiş)353-362
Sayfa sayısı10
DergiInorganica Chimica Acta
Hacim394
DOI'lar
Yayın durumuYayınlandı - 1 Oca 2013

Finansman

This work was supported by TUBITAK (110T527) and Research Fund of Istanbul Technical University.

FinansörlerFinansör numarası
TUBITAK110T527
Istanbul Teknik Üniversitesi

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