The effects of zinc(II)phthalocyanine photosensitizers on biological activities of epitheloid cervix carcinoma cells and precise determination of absorbed fluence at a specific wavelength

Asiye Gök Yurttaş, Altuğ Mert Sevim, Kamil Çınar, Göknur Yaşa Atmaca, Ali Erdoğmuş, Ahmet Gül*

*Bu çalışma için yazışmadan sorumlu yazar

Araştırma sonucu: ???type-name???Makalebilirkişi

17 Atıf (Scopus)

Özet

Photodynamic therapy (PDT) is an alternative way to treat the cancer non-surgically with minimum harm, in which a specific light and light sensitive photosensitizer (PS) is used. This study deals with the utilization of zinc photosensitizers (λmax ∼700 nm) from the group of phthalocyanines in photodynamic therapy. The photosensitizers differed in bearing either tetra- or octa-mercaptopropionic acid groups. The phthalocyanines (L1ZnPc and DipZnPc) were tested in cancer cell line, HeLa cell (epitheloid cervix carcinoma), by dark and light cytotoxicity. The photophysico-chemical properties of the resulting zinc photosensitizers were analyzed and to investigate the singlet oxygen's efficiency, photochemical properties were determined. For L1ZnPc, the singlet oxygen quantum yield was ΦΔ = 0.41 and for DipZnPc, the value was ΦΔ = 0.27. In addition to the experimental outcomes, this study handles detailed calculations of the absorbed light dose by the photosensitizer at a specific wavelength. In the light of this study, the researchers could get the insight of the precise amount of energy delivered to the cells by a laser beam for critical applications. The absorbed dose of the laser irradiation was calculated within a true wavelength range that is the most detailed explanation in literature.

Orijinal dilİngilizce
Makale numarası110012
DergiDyes and Pigments
Hacim198
DOI'lar
Yayın durumuYayınlandı - Şub 2022

Bibliyografik not

Publisher Copyright:
© 2021 Elsevier Ltd

Finansman

This work was supported by the Research Fund of the Technical University of Istanbul . AG thanks Turkish Academy of Sciences (TUBA) for partial support. We thank to Cem Uğuz for his valuable contribution in the process of the developing the laser system for this research. This work was supported by the Research Fund of the Technical University of Istanbul. AG thanks Turkish Academy of Sciences (TUBA) for partial support. We thank to Cem U?uz for his valuable contribution in the process of the developing the laser system for this research.

FinansörlerFinansör numarası
TUBA
Türkiye Bilimler Akademisi
Istanbul Teknik Üniversitesi

    Parmak izi

    The effects of zinc(II)phthalocyanine photosensitizers on biological activities of epitheloid cervix carcinoma cells and precise determination of absorbed fluence at a specific wavelength' araştırma başlıklarına git. Birlikte benzersiz bir parmak izi oluştururlar.

    Alıntı Yap