The effects of Alzheimer's disease related striatal pathologic changes on the fractional amplitude of low-frequency fluctuations

Yuksel Cakir

doi:10.1080/10255842.2020.1801653

The effects of Alzheimer's disease related striatal pathologic changes on the fractional amplitude of low-frequency fluctuations

Yuksel Cakir^*

^*Bu çalışma için yazışmadan sorumlu yazar

Elektronik ve Hab.Müh.Bölümü

Université de Strasbourg

Araştırma sonucu: ???type-name??? › Makale › bilirkişi

Özet

This paper aims to correlate Alzheimer's disease (AD) related striatal pathologic changes with the fractional amplitude of low-frequency fluctuations (fALLF) in the blood oxygenation level-dependent (BOLD) signal in the resting state functional Magnetic Resonance Imaging (rs-fMRI). A dopamine modulated Izikhevich neuron model based network of striatum region is constructed. Balloon–Windkessel hemodynamic model is used to obtain BOLD signals. fALFF differences between two frequency bands (slow-5:0.01–0.027 Hz; slow-4:0.027–0.073 Hz) are investigated in the case of dopamine depletion, decrease in the synaptic connectivity and the input from cortical and thalamic region, assumed that they are the degenerations occurring in AD.

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	1347-1359
Sayfa sayısı	13
Dergi	Computer Methods in Biomechanics and Biomedical Engineering
Hacim	23
Basın numarası	16
DOI'lar	https://doi.org/10.1080/10255842.2020.1801653
Yayın durumu	Yayınlandı - 2020

Bibliyografik not

Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.

Belgeye Erişim

10.1080/10255842.2020.1801653

Diğer Dosyalar ve Linkler

Link to publication in Scopus

Alıntı Yap

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title = "The effects of Alzheimer's disease related striatal pathologic changes on the fractional amplitude of low-frequency fluctuations",

abstract = "This paper aims to correlate Alzheimer's disease (AD) related striatal pathologic changes with the fractional amplitude of low-frequency fluctuations (fALLF) in the blood oxygenation level-dependent (BOLD) signal in the resting state functional Magnetic Resonance Imaging (rs-fMRI). A dopamine modulated Izikhevich neuron model based network of striatum region is constructed. Balloon–Windkessel hemodynamic model is used to obtain BOLD signals. fALFF differences between two frequency bands (slow-5:0.01–0.027 Hz; slow-4:0.027–0.073 Hz) are investigated in the case of dopamine depletion, decrease in the synaptic connectivity and the input from cortical and thalamic region, assumed that they are the degenerations occurring in AD.",

keywords = "Izikhevich neuron model, bold signal, computational modeling, fALFF, hemodynamic model, striatum",

author = "Yuksel Cakir",

note = "Publisher Copyright: {\textcopyright} 2020 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2020",

doi = "10.1080/10255842.2020.1801653",

language = "English",

volume = "23",

pages = "1347--1359",

journal = "Computer Methods in Biomechanics and Biomedical Engineering",

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T1 - The effects of Alzheimer's disease related striatal pathologic changes on the fractional amplitude of low-frequency fluctuations

AU - Cakir, Yuksel

PY - 2020

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AB - This paper aims to correlate Alzheimer's disease (AD) related striatal pathologic changes with the fractional amplitude of low-frequency fluctuations (fALLF) in the blood oxygenation level-dependent (BOLD) signal in the resting state functional Magnetic Resonance Imaging (rs-fMRI). A dopamine modulated Izikhevich neuron model based network of striatum region is constructed. Balloon–Windkessel hemodynamic model is used to obtain BOLD signals. fALFF differences between two frequency bands (slow-5:0.01–0.027 Hz; slow-4:0.027–0.073 Hz) are investigated in the case of dopamine depletion, decrease in the synaptic connectivity and the input from cortical and thalamic region, assumed that they are the degenerations occurring in AD.

KW - Izikhevich neuron model

KW - bold signal

KW - computational modeling

KW - fALFF

KW - hemodynamic model

KW - striatum

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U2 - 10.1080/10255842.2020.1801653

DO - 10.1080/10255842.2020.1801653

M3 - Article

C2 - 32749154

AN - SCOPUS:85088983365

SN - 1025-5842

VL - 23

SP - 1347

EP - 1359

JO - Computer Methods in Biomechanics and Biomedical Engineering

JF - Computer Methods in Biomechanics and Biomedical Engineering

IS - 16

ER -

The effects of Alzheimer's disease related striatal pathologic changes on the fractional amplitude of low-frequency fluctuations

Özet

Bibliyografik not

Belgeye Erişim

Diğer Dosyalar ve Linkler

Parmak izi

Alıntı Yap