Synthesis of novel DNA-interacting phthalocyanines

Canan Uslan; B. Şebnem Sesalan

doi:10.1016/j.dyepig.2011.12.003

Synthesis of novel DNA-interacting phthalocyanines

Canan Uslan
, B. Şebnem Sesalan^*

^*Bu çalışma için yazışmadan sorumlu yazar

Kimya Bölümü

Istanbul Technical University

Araştırma sonucu: Dergiye katkı › Makale › bilirkişi

47 Atıf (Scopus)

Özet

The new copper hexamethyleneimino-ethoxy substituted phthalocyanine (pc) (2) and its quaternized derivative (2Q) were synthesized. The interaction of quaternized copper (2Q), quaternized cobalt (3Q) and zinc (4Q) phthalocyanines (pcs) with calf thymus (CT) DNA was investigated by UV/Vis spectrophotometric methods and gel electrophoresis. With the addition of pcs, the change in the thermal denaturation profile of DNA was observed. The results indicated that these molecules exhibit efficient DNA binding activity. Generation of singlet oxygen by 2 and 2Q and photocleavage of CT-DNA were determined. All the experimental data proved that these water soluble pcs can act as active components in the photocleavage of DNA.

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	127-135
Sayfa sayısı	9
Dergi	Dyes and Pigments
Hacim	94
Basın numarası	1
DOI'lar	https://doi.org/10.1016/j.dyepig.2011.12.003
Yayın durumu	Yayınlandı - Tem 2012

Finansman

This work was supported by TUBITAK ( 110T527 ) and Research Fund of Istanbul Technical University .

Finansörler	Finansör numarası
TUBITAK	110T527
Istanbul Teknik Üniversitesi

Belgeye Erişim

10.1016/j.dyepig.2011.12.003

Diğer Dosyalar ve Linkler

Link to publication in Scopus

Alıntı Yap

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title = "Synthesis of novel DNA-interacting phthalocyanines",

abstract = "The new copper hexamethyleneimino-ethoxy substituted phthalocyanine (pc) (2) and its quaternized derivative (2Q) were synthesized. The interaction of quaternized copper (2Q), quaternized cobalt (3Q) and zinc (4Q) phthalocyanines (pcs) with calf thymus (CT) DNA was investigated by UV/Vis spectrophotometric methods and gel electrophoresis. With the addition of pcs, the change in the thermal denaturation profile of DNA was observed. The results indicated that these molecules exhibit efficient DNA binding activity. Generation of singlet oxygen by 2 and 2Q and photocleavage of CT-DNA were determined. All the experimental data proved that these water soluble pcs can act as active components in the photocleavage of DNA.",

keywords = "DNA, Gel electrophoresis, Metallophthalocyanine, Photosensitizer, Quaternization, Singlet oxygen",

author = "Canan Uslan and \{{\c S}ebnem Sesalan\}, B.",

year = "2012",

month = jul,

doi = "10.1016/j.dyepig.2011.12.003",

language = "English",

volume = "94",

pages = "127--135",

journal = "Dyes and Pigments",

issn = "0143-7208",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Synthesis of novel DNA-interacting phthalocyanines

AU - Uslan, Canan

AU - Şebnem Sesalan, B.

PY - 2012/7

Y1 - 2012/7

N2 - The new copper hexamethyleneimino-ethoxy substituted phthalocyanine (pc) (2) and its quaternized derivative (2Q) were synthesized. The interaction of quaternized copper (2Q), quaternized cobalt (3Q) and zinc (4Q) phthalocyanines (pcs) with calf thymus (CT) DNA was investigated by UV/Vis spectrophotometric methods and gel electrophoresis. With the addition of pcs, the change in the thermal denaturation profile of DNA was observed. The results indicated that these molecules exhibit efficient DNA binding activity. Generation of singlet oxygen by 2 and 2Q and photocleavage of CT-DNA were determined. All the experimental data proved that these water soluble pcs can act as active components in the photocleavage of DNA.

AB - The new copper hexamethyleneimino-ethoxy substituted phthalocyanine (pc) (2) and its quaternized derivative (2Q) were synthesized. The interaction of quaternized copper (2Q), quaternized cobalt (3Q) and zinc (4Q) phthalocyanines (pcs) with calf thymus (CT) DNA was investigated by UV/Vis spectrophotometric methods and gel electrophoresis. With the addition of pcs, the change in the thermal denaturation profile of DNA was observed. The results indicated that these molecules exhibit efficient DNA binding activity. Generation of singlet oxygen by 2 and 2Q and photocleavage of CT-DNA were determined. All the experimental data proved that these water soluble pcs can act as active components in the photocleavage of DNA.

KW - DNA

KW - Gel electrophoresis

KW - Metallophthalocyanine

KW - Photosensitizer

KW - Quaternization

KW - Singlet oxygen

UR - https://www.scopus.com/pages/publications/84855181827

U2 - 10.1016/j.dyepig.2011.12.003

DO - 10.1016/j.dyepig.2011.12.003

M3 - Article

AN - SCOPUS:84855181827

SN - 0143-7208

VL - 94

SP - 127

EP - 135

JO - Dyes and Pigments

JF - Dyes and Pigments

IS - 1

ER -

Synthesis of novel DNA-interacting phthalocyanines

Özet

Finansman

Belgeye Erişim

Diğer Dosyalar ve Linkler

Parmak izi

Alıntı Yap