@article{2322926b51c7493b9e0fbd71efbeca74,
title = "Synthesis of diarylmethylamines via palladium-catalyzed regioselective arylation of 1,1,3-triaryl-2-azaallyl anions",
abstract = "Diarylmethylamines are of great interest due to their prevalence in pharmaceutical chemistry. As a result, new methods for their synthesis are in demand. Herein, we report a versatile protocol for the synthesis of diarylmethylamine derivatives involving palladium-catalyzed arylation of in situ generated 2-azaallyl anion intermediates. The 2-azaallyl anions are generated by reversible deprotonation of readily available aldimine and ketimine precursors. Importantly, the arylated aldimine and ketimine products do not undergo isomerization under the reaction conditions. Scale-up of the arylation and hydrolysis of the resulting products to furnish diarylmethylamines were also successfully performed. This journal is",
author = "Minyan Li and Baris Y{\"u}cel and Javier Adrio and Ana Bellomo and Walsh, \{Patrick J.\}",
year = "2014",
month = jun,
doi = "10.1039/c3sc53526f",
language = "English",
volume = "5",
pages = "2383--2391",
journal = "Chemical Science",
issn = "2041-6520",
publisher = "Royal Society of Chemistry",
number = "6",
}