Study of competitive protein-drug binding by capillary electrophoresis

F. Bedia Erim Berker

Study of competitive protein-drug binding by capillary electrophoresis

F. Bedia Erim Berker^*

^*Bu çalışma için yazışmadan sorumlu yazar

Kimya Bölümü

Araştırma sonucu: Dergiye katkı › Makale › bilirkişi

Özet

The competitive affinity of two drugs (the anticoagulant warfarin and the diuretic furosemide) to bovine serum albumin (BSA) is studied by capillary electrophoresis. The competition of these two drugs for the same site on BSA is shown. The binding constant between the displacer drug (furosemide) and BSA is estimated relative to the known warfarin-BSA binding constant.

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	65-69
Sayfa sayısı	5
Dergi	ARI Bulletin of the Istanbul Technical University
Hacim	53
Basın numarası	1
Yayın durumu	Yayınlandı - 2003

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Alıntı Yap

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title = "Study of competitive protein-drug binding by capillary electrophoresis",

abstract = "The competitive affinity of two drugs (the anticoagulant warfarin and the diuretic furosemide) to bovine serum albumin (BSA) is studied by capillary electrophoresis. The competition of these two drugs for the same site on BSA is shown. The binding constant between the displacer drug (furosemide) and BSA is estimated relative to the known warfarin-BSA binding constant.",

keywords = "Binding constant, Capillary electrophoresis, Drug, Protein",

author = "Berker, \{F. Bedia Erim\}",

year = "2003",

language = "English",

volume = "53",

pages = "65--69",

journal = "ARI Bulletin of the Istanbul Technical University",

issn = "1434-5641",

publisher = "Istanbul Technical University",

number = "1",

}

TY - JOUR

T1 - Study of competitive protein-drug binding by capillary electrophoresis

AU - Berker, F. Bedia Erim

PY - 2003

Y1 - 2003

N2 - The competitive affinity of two drugs (the anticoagulant warfarin and the diuretic furosemide) to bovine serum albumin (BSA) is studied by capillary electrophoresis. The competition of these two drugs for the same site on BSA is shown. The binding constant between the displacer drug (furosemide) and BSA is estimated relative to the known warfarin-BSA binding constant.

AB - The competitive affinity of two drugs (the anticoagulant warfarin and the diuretic furosemide) to bovine serum albumin (BSA) is studied by capillary electrophoresis. The competition of these two drugs for the same site on BSA is shown. The binding constant between the displacer drug (furosemide) and BSA is estimated relative to the known warfarin-BSA binding constant.

KW - Binding constant

KW - Capillary electrophoresis

KW - Drug

KW - Protein

UR - https://www.scopus.com/pages/publications/33747458889

M3 - Article

AN - SCOPUS:33747458889

SN - 1434-5641

VL - 53

SP - 65

EP - 69

JO - ARI Bulletin of the Istanbul Technical University

JF - ARI Bulletin of the Istanbul Technical University

IS - 1

ER -

Study of competitive protein-drug binding by capillary electrophoresis

Özet

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