Spectroscopic and thermodynamic approach to the interaction of nonperipherally substituted cationic phthalocyanines with calf thymus (CT)-DNA

Sevgican Tuncer, Ibrahim Ozçeşmeci, Behice Şebnem Sesalan, Ayfer Kalkan Burat*

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Araştırma sonucu: ???type-name???Makalebilirkişi

4 Atıf (Scopus)

Özet

Novel, nonperipherally tetrasubstituted cationic metal-free and metallophthalocyanines (Zn, In) were synthesized in the present study. The binding constants, the disappearance of quenching effect of all cationic phthalocyanines on the fluorescence intensity of SYBR Green–disodium salt of deoxyribonucleic acid (DNA) from calf thymus complex, and the changes in Tm of double helix DNA with thermal denaturation profile were investigated by UV-Vis and fluorescence spectrophotometric methods. To investigate the spontaneity of the reactions between DNA and novel quaternized phthalocyanines in buffer, thermodynamic parameters were employed.

Orijinal dilİngilizce
Sayfa (başlangıç-bitiş)274-290
Sayfa sayısı17
DergiTurkish Journal of Chemistry
Hacim42
Basın numarası2
DOI'lar
Yayın durumuYayınlandı - 2018

Bibliyografik not

Publisher Copyright:
© TÜBITAK.

Finansman

This work was supported by the Scientific and Technological Research Council of Turkey (TÜBİTAK, Project no: 115Z063).

FinansörlerFinansör numarası
TÜBİTAK
Türkiye Bilimsel ve Teknolojik Araştirma Kurumu115Z063

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