Spectrophotometric determination of furosemide in pharmaceutical dosage forms using complex formation with Cu(II)

A. Gölcü

doi:10.1134/S1061934806080053

Spectrophotometric determination of furosemide in pharmaceutical dosage forms using complex formation with Cu(II)

A. Gölcü^*

^*Bu çalışma için yazışmadan sorumlu yazar

Kahramanmaras Sutcu Imam University

Araştırma sonucu: ???type-name??? › Makale › bilirkişi

30 Atıf (Scopus)

Özet

A simple, sensitive, and accurate spectrophotometric method has been developed for the assay of furosemide (FUR), which is based on the complexation of the drug with copper(II) at pH 3.2 using Mclivaine buffer solution to produce a green adduct. The latter has maximum absorbance at 790 nm and obeys Beer's law within the concentration range 5-30 μg/mL. Regression analysis of the calibration data showed a good correlation coefficient (r = 0.9997) with minimum detection limit of 0.23 μg/mL. The proposed procedure has been successfully applied to the determination of this drug in tablets. In addition, the spectral data and stability constant for the mononuclear copper(II) complex of furosemide (CuFUR₂(MeOH)₂) are reported.

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	748-754
Sayfa sayısı	7
Dergi	Journal of Analytical Chemistry
Hacim	61
Basın numarası	8
DOI'lar	https://doi.org/10.1134/S1061934806080053
Yayın durumu	Yayınlandı - Ağu 2006
Harici olarak yayınlandı	Evet

Finansman

ACKNOWLEDGMENTS The author gratefully acknowledges the financial support of the Research Foundation (project no. 2004-4/6) of Kahramanmaras¸ Sütçü ˙mam University, Kahr-amanmaras¸, Turkey, and thanks Prof. Dr. Selahattin Serin, Prof. Dr. Sibel A. Ozkan, and Chem. Mustafa Dolaz for their useful suggestions.

Finansörler	Finansör numarası
ASCRS Research Foundation	2004-4/6

Belgeye Erişim

10.1134/S1061934806080053

Diğer Dosyalar ve Linkler

Link to publication in Scopus

Alıntı Yap

@article{45e12e065f7342e28712441c649eb031,

title = "Spectrophotometric determination of furosemide in pharmaceutical dosage forms using complex formation with Cu(II)",

abstract = "A simple, sensitive, and accurate spectrophotometric method has been developed for the assay of furosemide (FUR), which is based on the complexation of the drug with copper(II) at pH 3.2 using Mclivaine buffer solution to produce a green adduct. The latter has maximum absorbance at 790 nm and obeys Beer's law within the concentration range 5-30 μg/mL. Regression analysis of the calibration data showed a good correlation coefficient (r = 0.9997) with minimum detection limit of 0.23 μg/mL. The proposed procedure has been successfully applied to the determination of this drug in tablets. In addition, the spectral data and stability constant for the mononuclear copper(II) complex of furosemide (CuFUR2(MeOH)2) are reported.",

author = "A. G{\"o}lc{\"u}",

year = "2006",

month = aug,

doi = "10.1134/S1061934806080053",

language = "English",

volume = "61",

pages = "748--754",

journal = "Journal of Analytical Chemistry",

issn = "1061-9348",

publisher = "Pleiades Publishing",

number = "8",

}

TY - JOUR

T1 - Spectrophotometric determination of furosemide in pharmaceutical dosage forms using complex formation with Cu(II)

AU - Gölcü, A.

PY - 2006/8

Y1 - 2006/8

N2 - A simple, sensitive, and accurate spectrophotometric method has been developed for the assay of furosemide (FUR), which is based on the complexation of the drug with copper(II) at pH 3.2 using Mclivaine buffer solution to produce a green adduct. The latter has maximum absorbance at 790 nm and obeys Beer's law within the concentration range 5-30 μg/mL. Regression analysis of the calibration data showed a good correlation coefficient (r = 0.9997) with minimum detection limit of 0.23 μg/mL. The proposed procedure has been successfully applied to the determination of this drug in tablets. In addition, the spectral data and stability constant for the mononuclear copper(II) complex of furosemide (CuFUR2(MeOH)2) are reported.

AB - A simple, sensitive, and accurate spectrophotometric method has been developed for the assay of furosemide (FUR), which is based on the complexation of the drug with copper(II) at pH 3.2 using Mclivaine buffer solution to produce a green adduct. The latter has maximum absorbance at 790 nm and obeys Beer's law within the concentration range 5-30 μg/mL. Regression analysis of the calibration data showed a good correlation coefficient (r = 0.9997) with minimum detection limit of 0.23 μg/mL. The proposed procedure has been successfully applied to the determination of this drug in tablets. In addition, the spectral data and stability constant for the mononuclear copper(II) complex of furosemide (CuFUR2(MeOH)2) are reported.

UR - http://www.scopus.com/inward/record.url?scp=33746612077&partnerID=8YFLogxK

U2 - 10.1134/S1061934806080053

DO - 10.1134/S1061934806080053

M3 - Article

AN - SCOPUS:33746612077

SN - 1061-9348

VL - 61

SP - 748

EP - 754

JO - Journal of Analytical Chemistry

JF - Journal of Analytical Chemistry

IS - 8

ER -

Spectrophotometric determination of furosemide in pharmaceutical dosage forms using complex formation with Cu(II)

Özet

Finansman

Belgeye Erişim

Diğer Dosyalar ve Linkler

Parmak izi

Alıntı Yap