Silver nanoparticle-coated polyhydroxyalkanoate based electrospun fibers for wound dressing applications

Ozlem Ipek Kalaoglu-Altan, Havva Baskan, Timo Meireman, Pooja Basnett, Bahareh Azimi, Alessandra Fusco, Niccola Funel, Giovanna Donnarumma, Andrea Lazzeri, Ipsita Roy, Serena Danti, Karen De Clerck*

*Bu çalışma için yazışmadan sorumlu yazar

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14 Atıf (Scopus)

Özet

Wound dressings are high performance and high value products which can improve the regeneration of damaged skin. In these products, bioresorption and biocompatibility play a key role. The aim of this study is to provide progress in this area via nanofabrication and antimicrobial natural materials. Polyhydroxyalkanoates (PHAs) are a bio-based family of polymers that possess high biocompatibility and skin regenerative properties. In this study, a blend of poly(3-hydroxybutyrate) (P(3HB)) and poly(3-hydroxyoctanoate-co-3-hydroxy decanoate) (P(3HO-co-3HD)) was electrospun into P(3HB))/P(3HO-co-3HD) nanofibers to obtain materials with a high surface area and good han-dling performance. The nanofibers were then modified with silver nanoparticles (AgNPs) via the dip-coating method. The silver-containing nanofiber meshes showed good cytocompatibility and interesting immunomodulatory properties in vitro, together with the capability of stimulating the human beta defensin 2 and cytokeratin expression in human keratinocytes (HaCaT cells), which makes them promising materials for wound dressing applications.

Orijinal dilİngilizce
Makale numarası4907
DergiMaterials
Hacim14
Basın numarası17
DOI'lar
Yayın durumuYayınlandı - Eyl 2021

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© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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