Polysulfone-graft-poly(ethylene glycol) graft copolymers for surface modification of polysulfone membranes

Jane Y. Park; Metin H. Acar; Ariya Akthakul; William Kuhlman; Anne M. Mayes

doi:10.1016/j.biomaterials.2005.07.010

Polysulfone-graft-poly(ethylene glycol) graft copolymers for surface modification of polysulfone membranes

Jane Y. Park
, Metin H. Acar
, Ariya Akthakul
, William Kuhlman
, Anne M. Mayes^*

^*Bu çalışma için yazışmadan sorumlu yazar

Massachusetts Institute of Technology

Araştırma sonucu: Dergiye katkı › Makale › bilirkişi

330 Atıf (Scopus)

Özet

Amphiphilic graft copolymers having polysulfone (PSf) backbones and poly(ethylene glycol) (PEG) side chains were synthesized via reaction of an alkoxide formed from PEG and a base (sodium hydride) with chloromethylated polysulfone. The resulting polysulfone-graft-poly(ethylene glycol), PSf-g-PEG, materials were hydrophilic but water insoluble, rendering them potentially useful as biomaterial coatings. PSf-g-PEG films exhibited high resistance to protein adsorption and cell attachment. When used as an additive in PSf membranes prepared by immersion precipitation, the graft copolymer preferentially segregates to the membrane surface, delivering enhanced wettability, porosity and protein resistance compared to unmodified PSf membranes. The surface properties of PSf-g-PEG modified membranes render them desirable candidates for hemodialysis.

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	856-865
Sayfa sayısı	10
Dergi	Biomaterials
Hacim	27
Basın numarası	6
DOI'lar	https://doi.org/10.1016/j.biomaterials.2005.07.010
Yayın durumu	Yayınlandı - Şub 2006
Harici olarak yayınlandı	Evet

Finansman

Financial support for this work was provided by the US Office of Naval Research under award N00014-02-1-0343, and grant 1R0GM59870-01 from the National Institute of Health. This work made use of MRSEC Shared Experimental Facilities support by the National Science Foundation under Award no. DMR-0213282. Jane Y. Park acknowledges the support of the National Science Foundation through the Graduate Student Fellowship program.

Finansörler	Finansör numarası
National Institute of Health
US Office of Naval Research	N00014-02-1-0343, 1R0GM59870-01
National Science Foundation
National Institute of General Medical Sciences	R01GM059870

Belgeye Erişim

10.1016/j.biomaterials.2005.07.010

Diğer Dosyalar ve Linkler

Link to publication in Scopus

Alıntı Yap

@article{1023a7d9079d41e083c54e623285700a,

title = "Polysulfone-graft-poly(ethylene glycol) graft copolymers for surface modification of polysulfone membranes",

abstract = "Amphiphilic graft copolymers having polysulfone (PSf) backbones and poly(ethylene glycol) (PEG) side chains were synthesized via reaction of an alkoxide formed from PEG and a base (sodium hydride) with chloromethylated polysulfone. The resulting polysulfone-graft-poly(ethylene glycol), PSf-g-PEG, materials were hydrophilic but water insoluble, rendering them potentially useful as biomaterial coatings. PSf-g-PEG films exhibited high resistance to protein adsorption and cell attachment. When used as an additive in PSf membranes prepared by immersion precipitation, the graft copolymer preferentially segregates to the membrane surface, delivering enhanced wettability, porosity and protein resistance compared to unmodified PSf membranes. The surface properties of PSf-g-PEG modified membranes render them desirable candidates for hemodialysis.",

keywords = "Dialysis, Membrane, Polyethylene glycol, Polysulfone, Protein resistance, Surface modification",

author = "Park, \{Jane Y.\} and Acar, \{Metin H.\} and Ariya Akthakul and William Kuhlman and Mayes, \{Anne M.\}",

year = "2006",

month = feb,

doi = "10.1016/j.biomaterials.2005.07.010",

language = "English",

volume = "27",

pages = "856--865",

journal = "Biomaterials",

issn = "0142-9612",

publisher = "Elsevier Ltd",

number = "6",

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TY - JOUR

T1 - Polysulfone-graft-poly(ethylene glycol) graft copolymers for surface modification of polysulfone membranes

AU - Park, Jane Y.

AU - Acar, Metin H.

AU - Akthakul, Ariya

AU - Kuhlman, William

AU - Mayes, Anne M.

PY - 2006/2

Y1 - 2006/2

N2 - Amphiphilic graft copolymers having polysulfone (PSf) backbones and poly(ethylene glycol) (PEG) side chains were synthesized via reaction of an alkoxide formed from PEG and a base (sodium hydride) with chloromethylated polysulfone. The resulting polysulfone-graft-poly(ethylene glycol), PSf-g-PEG, materials were hydrophilic but water insoluble, rendering them potentially useful as biomaterial coatings. PSf-g-PEG films exhibited high resistance to protein adsorption and cell attachment. When used as an additive in PSf membranes prepared by immersion precipitation, the graft copolymer preferentially segregates to the membrane surface, delivering enhanced wettability, porosity and protein resistance compared to unmodified PSf membranes. The surface properties of PSf-g-PEG modified membranes render them desirable candidates for hemodialysis.

AB - Amphiphilic graft copolymers having polysulfone (PSf) backbones and poly(ethylene glycol) (PEG) side chains were synthesized via reaction of an alkoxide formed from PEG and a base (sodium hydride) with chloromethylated polysulfone. The resulting polysulfone-graft-poly(ethylene glycol), PSf-g-PEG, materials were hydrophilic but water insoluble, rendering them potentially useful as biomaterial coatings. PSf-g-PEG films exhibited high resistance to protein adsorption and cell attachment. When used as an additive in PSf membranes prepared by immersion precipitation, the graft copolymer preferentially segregates to the membrane surface, delivering enhanced wettability, porosity and protein resistance compared to unmodified PSf membranes. The surface properties of PSf-g-PEG modified membranes render them desirable candidates for hemodialysis.

KW - Dialysis

KW - Membrane

KW - Polyethylene glycol

KW - Polysulfone

KW - Protein resistance

KW - Surface modification

UR - https://www.scopus.com/pages/publications/26944495686

U2 - 10.1016/j.biomaterials.2005.07.010

DO - 10.1016/j.biomaterials.2005.07.010

M3 - Article

C2 - 16105681

AN - SCOPUS:26944495686

SN - 0142-9612

VL - 27

SP - 856

EP - 865

JO - Biomaterials

JF - Biomaterials

IS - 6

ER -

Polysulfone-graft-poly(ethylene glycol) graft copolymers for surface modification of polysulfone membranes

Özet

Finansman

Belgeye Erişim

Diğer Dosyalar ve Linkler

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