Polysulfone based amphiphilic graft copolymers by click chemistry as bioinert membranes

Gorkem Yilmaz; Hojjat Toiserkani; Dilek Odaci Demirkol; Serhan Sakarya; Suna Timur; Lokman Torun; Yusuf Yagci

doi:10.1016/j.msec.2011.03.010

Polysulfone based amphiphilic graft copolymers by click chemistry as bioinert membranes

Gorkem Yilmaz, Hojjat Toiserkani, Dilek Odaci Demirkol, Serhan Sakarya, Suna Timur^*, Lokman Torun, Yusuf Yagci

^*Bu çalışma için yazışmadan sorumlu yazar

Kimya Bölümü

Araştırma sonucu: Dergiye katkı › Makale › bilirkişi

37 Atıf (Scopus)

Özet

A series of well-defined amphiphilic graft copolymers with hydrophobic polysulfone (PSU) as backbones and hydrophilic poly(ethylene glycol) (PEG) as side chains were synthesized and characterized. For this purpose, PSUs were converted to azido-functionalized polymers by successive chloromethylation and azidation processes to give clickable PSUs. Then, the ω-hydroxyl function of the commercially available PEG-OH was converted into propargyl functionality by simple esterification process. Ultimately, the alkyne functionalized PEO was successfully grafted onto the PSUs by click chemistry. The final polymers and intermediates at various stages were characterized by ¹H NMR, FT-IR, and GPC techniques. The bioinert character of PEG grafted PSU was confirmed by static protein adsorption and prokaryotic and eukaryotic cell adhesion studies, and compared to that of unmodified PSU.

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	1091-1097
Sayfa sayısı	7
Dergi	Materials Science and Engineering C
Hacim	31
Basın numarası	5
DOI'lar	https://doi.org/10.1016/j.msec.2011.03.010
Yayın durumu	Yayınlandı - 20 Tem 2011

Finansman

The authors thank Istanbul Technical University, Research Fund and the State Planning Organization of Turkey (DPT) for financial support. One of the authors (Y.Y.) thanks the Turkish Academy of Sciences for partial financial support.

Finansörler	Finansör numarası
DPT
State Planning Organization of Turkey
Türkiye Bilimler Akademisi
Istanbul Teknik Üniversitesi

Belgeye Erişim

10.1016/j.msec.2011.03.010

Diğer Dosyalar ve Linkler

Link to publication in Scopus

Alıntı Yap

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title = "Polysulfone based amphiphilic graft copolymers by click chemistry as bioinert membranes",

abstract = "A series of well-defined amphiphilic graft copolymers with hydrophobic polysulfone (PSU) as backbones and hydrophilic poly(ethylene glycol) (PEG) as side chains were synthesized and characterized. For this purpose, PSUs were converted to azido-functionalized polymers by successive chloromethylation and azidation processes to give clickable PSUs. Then, the ω-hydroxyl function of the commercially available PEG-OH was converted into propargyl functionality by simple esterification process. Ultimately, the alkyne functionalized PEO was successfully grafted onto the PSUs by click chemistry. The final polymers and intermediates at various stages were characterized by 1H NMR, FT-IR, and GPC techniques. The bioinert character of PEG grafted PSU was confirmed by static protein adsorption and prokaryotic and eukaryotic cell adhesion studies, and compared to that of unmodified PSU.",

keywords = "Amphiphilic graft copolymer, Bio-inertness, Click chemistry, Hydrophilic segments, Poly(ethylene glycol), Polysulfone",

author = "Gorkem Yilmaz and Hojjat Toiserkani and Demirkol, {Dilek Odaci} and Serhan Sakarya and Suna Timur and Lokman Torun and Yusuf Yagci",

year = "2011",

month = jul,

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doi = "10.1016/j.msec.2011.03.010",

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T1 - Polysulfone based amphiphilic graft copolymers by click chemistry as bioinert membranes

AU - Yilmaz, Gorkem

AU - Toiserkani, Hojjat

AU - Demirkol, Dilek Odaci

AU - Sakarya, Serhan

AU - Timur, Suna

AU - Torun, Lokman

AU - Yagci, Yusuf

PY - 2011/7/20

Y1 - 2011/7/20

N2 - A series of well-defined amphiphilic graft copolymers with hydrophobic polysulfone (PSU) as backbones and hydrophilic poly(ethylene glycol) (PEG) as side chains were synthesized and characterized. For this purpose, PSUs were converted to azido-functionalized polymers by successive chloromethylation and azidation processes to give clickable PSUs. Then, the ω-hydroxyl function of the commercially available PEG-OH was converted into propargyl functionality by simple esterification process. Ultimately, the alkyne functionalized PEO was successfully grafted onto the PSUs by click chemistry. The final polymers and intermediates at various stages were characterized by 1H NMR, FT-IR, and GPC techniques. The bioinert character of PEG grafted PSU was confirmed by static protein adsorption and prokaryotic and eukaryotic cell adhesion studies, and compared to that of unmodified PSU.

AB - A series of well-defined amphiphilic graft copolymers with hydrophobic polysulfone (PSU) as backbones and hydrophilic poly(ethylene glycol) (PEG) as side chains were synthesized and characterized. For this purpose, PSUs were converted to azido-functionalized polymers by successive chloromethylation and azidation processes to give clickable PSUs. Then, the ω-hydroxyl function of the commercially available PEG-OH was converted into propargyl functionality by simple esterification process. Ultimately, the alkyne functionalized PEO was successfully grafted onto the PSUs by click chemistry. The final polymers and intermediates at various stages were characterized by 1H NMR, FT-IR, and GPC techniques. The bioinert character of PEG grafted PSU was confirmed by static protein adsorption and prokaryotic and eukaryotic cell adhesion studies, and compared to that of unmodified PSU.

KW - Amphiphilic graft copolymer

KW - Bio-inertness

KW - Click chemistry

KW - Hydrophilic segments

KW - Poly(ethylene glycol)

KW - Polysulfone

UR - http://www.scopus.com/inward/record.url?scp=79956137929&partnerID=8YFLogxK

U2 - 10.1016/j.msec.2011.03.010

DO - 10.1016/j.msec.2011.03.010

M3 - Article

AN - SCOPUS:79956137929

SN - 0928-4931

VL - 31

SP - 1091

EP - 1097

JO - Materials Science and Engineering C

JF - Materials Science and Engineering C

IS - 5

ER -

Polysulfone based amphiphilic graft copolymers by click chemistry as bioinert membranes

Özet

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