Poly(N-isopropylacrylamide) based pH- and temperature-sensitive ampholytic hydrogels with tunable mechanical, swelling and drug release properties

Ceyda Şimşek; Candan Erbil

doi:10.1080/00914037.2021.1960333

Poly(N-isopropylacrylamide) based pH- and temperature-sensitive ampholytic hydrogels with tunable mechanical, swelling and drug release properties

Ceyda Şimşek, Candan Erbil^*

^*Bu çalışma için yazışmadan sorumlu yazar

Kimya Bölümü

Araştırma sonucu: Dergiye katkı › Makale › bilirkişi

2 Atıf (Scopus)

Özet

pH-/temperature-sensitive ampholytic poly(N-isopropylacrylamide) (PNIPAAm) hydrogels containing N-[3-(dimethylamino)propyl]methacrylamide-itaconic acid (DMAPMAAm-IA) and DMAPMAAm-AMPS (2-acrylamido-2-methylpropane sulfonic acid) comonomer pairs have been designed and then synthesized. The results showed that (i) disk diameters and transparencies in the range of pH 2–12 increased only with increasing content of AMPS in the ampholytic NIPAAm/DMAPMAAm/AMPS hydrogels containing 10.0 mol % of DMAPMAAm + AMPS mixtures; (ii) maximum compressive strengths of NIPAAm/IA (62.5 ± 10.0 kPa) was higher than NIPAAm/AMPS (26.9 ± 1.1 kPa) hydrogels in DDW at 37 °C. (iii) In case of DFNa release, the decreasing values of n (≈0.30–0.50) indicated that ampholytic PNIPAAm hydrogels served as diffusion barrier.

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	1148-1163
Sayfa sayısı	16
Dergi	International Journal of Polymeric Materials and Polymeric Biomaterials
Hacim	71
Basın numarası	15
DOI'lar	https://doi.org/10.1080/00914037.2021.1960333
Yayın durumu	Yayınlandı - 2022

Bibliyografik not

Publisher Copyright:
© 2021 Taylor & Francis Group, LLC.

Finansman

This work was supported by the Scientific Research Project Coordination Center of Istanbul Technical University (ITU) (Scientific Research Project Fund with the Project number 38387). We thank Dr. Gökhan Göksu for guidance on MATLABTM calculations.

Finansörler	Finansör numarası
Istanbul Teknik Üniversitesi	38387

Belgeye Erişim

10.1080/00914037.2021.1960333

Diğer Dosyalar ve Linkler

Link to publication in Scopus

Alıntı Yap

@article{24e5b215bff7408ba4d9b147766ec18d,

title = "Poly(N-isopropylacrylamide) based pH- and temperature-sensitive ampholytic hydrogels with tunable mechanical, swelling and drug release properties",

abstract = "pH-/temperature-sensitive ampholytic poly(N-isopropylacrylamide) (PNIPAAm) hydrogels containing N-[3-(dimethylamino)propyl]methacrylamide-itaconic acid (DMAPMAAm-IA) and DMAPMAAm-AMPS (2-acrylamido-2-methylpropane sulfonic acid) comonomer pairs have been designed and then synthesized. The results showed that (i) disk diameters and transparencies in the range of pH 2–12 increased only with increasing content of AMPS in the ampholytic NIPAAm/DMAPMAAm/AMPS hydrogels containing 10.0 mol % of DMAPMAAm + AMPS mixtures; (ii) maximum compressive strengths of NIPAAm/IA (62.5 ± 10.0 kPa) was higher than NIPAAm/AMPS (26.9 ± 1.1 kPa) hydrogels in DDW at 37 °C. (iii) In case of DFNa release, the decreasing values of n (≈0.30–0.50) indicated that ampholytic PNIPAAm hydrogels served as diffusion barrier.",

keywords = "2-acrylamido-2-methylpropane sulfonic acid, N-[3-(dimethylamino)propyl] methacrylamideItaconic acid, ampholytic poly(N-isopropylacrylamide) hydrogels, compression modulus, diclofenac sodium release, dynamic swelling",

author = "Ceyda {\c S}im{\c s}ek and Candan Erbil",

note = "Publisher Copyright: {\textcopyright} 2021 Taylor & Francis Group, LLC.",

year = "2022",

doi = "10.1080/00914037.2021.1960333",

language = "English",

volume = "71",

pages = "1148--1163",

journal = "International Journal of Polymeric Materials and Polymeric Biomaterials",

issn = "0091-4037",

publisher = "Taylor and Francis Ltd.",

number = "15",

}

TY - JOUR

T1 - Poly(N-isopropylacrylamide) based pH- and temperature-sensitive ampholytic hydrogels with tunable mechanical, swelling and drug release properties

AU - Şimşek, Ceyda

AU - Erbil, Candan

PY - 2022

Y1 - 2022

N2 - pH-/temperature-sensitive ampholytic poly(N-isopropylacrylamide) (PNIPAAm) hydrogels containing N-[3-(dimethylamino)propyl]methacrylamide-itaconic acid (DMAPMAAm-IA) and DMAPMAAm-AMPS (2-acrylamido-2-methylpropane sulfonic acid) comonomer pairs have been designed and then synthesized. The results showed that (i) disk diameters and transparencies in the range of pH 2–12 increased only with increasing content of AMPS in the ampholytic NIPAAm/DMAPMAAm/AMPS hydrogels containing 10.0 mol % of DMAPMAAm + AMPS mixtures; (ii) maximum compressive strengths of NIPAAm/IA (62.5 ± 10.0 kPa) was higher than NIPAAm/AMPS (26.9 ± 1.1 kPa) hydrogels in DDW at 37 °C. (iii) In case of DFNa release, the decreasing values of n (≈0.30–0.50) indicated that ampholytic PNIPAAm hydrogels served as diffusion barrier.

AB - pH-/temperature-sensitive ampholytic poly(N-isopropylacrylamide) (PNIPAAm) hydrogels containing N-[3-(dimethylamino)propyl]methacrylamide-itaconic acid (DMAPMAAm-IA) and DMAPMAAm-AMPS (2-acrylamido-2-methylpropane sulfonic acid) comonomer pairs have been designed and then synthesized. The results showed that (i) disk diameters and transparencies in the range of pH 2–12 increased only with increasing content of AMPS in the ampholytic NIPAAm/DMAPMAAm/AMPS hydrogels containing 10.0 mol % of DMAPMAAm + AMPS mixtures; (ii) maximum compressive strengths of NIPAAm/IA (62.5 ± 10.0 kPa) was higher than NIPAAm/AMPS (26.9 ± 1.1 kPa) hydrogels in DDW at 37 °C. (iii) In case of DFNa release, the decreasing values of n (≈0.30–0.50) indicated that ampholytic PNIPAAm hydrogels served as diffusion barrier.

KW - 2-acrylamido-2-methylpropane sulfonic acid

KW - N-[3-(dimethylamino)propyl] methacrylamideItaconic acid

KW - ampholytic poly(N-isopropylacrylamide) hydrogels

KW - compression modulus

KW - diclofenac sodium release

KW - dynamic swelling

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U2 - 10.1080/00914037.2021.1960333

DO - 10.1080/00914037.2021.1960333

M3 - Article

AN - SCOPUS:85113721939

SN - 0091-4037

VL - 71

SP - 1148

EP - 1163

JO - International Journal of Polymeric Materials and Polymeric Biomaterials

JF - International Journal of Polymeric Materials and Polymeric Biomaterials

IS - 15

ER -

Poly(N-isopropylacrylamide) based pH- and temperature-sensitive ampholytic hydrogels with tunable mechanical, swelling and drug release properties

Özet

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Finansman

Belgeye Erişim

Diğer Dosyalar ve Linkler

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