Photophysicochemical behaviour and antimicrobial properties of monocarboxy Mg (II) and Al (III) phthalocyanine-magnetite conjugates

Mopelola Abidemi Idowu; Solami Xego; Yasin Arslanoglu; John Mark; Edith Antunes; Tebello Nyokong

doi:10.1016/j.saa.2017.12.052

Photophysicochemical behaviour and antimicrobial properties of monocarboxy Mg (II) and Al (III) phthalocyanine-magnetite conjugates

Mopelola Abidemi Idowu^*
, Solami Xego
, Yasin Arslanoglu
, John Mark
, Edith Antunes
, Tebello Nyokong

^*Bu çalışma için yazışmadan sorumlu yazar

Temel Bilimler Bölümü

Rhodes University
Federal University of Agriculture, Abeokuta

Araştırma sonucu: Dergiye katkı › Makale › bilirkişi

26 Atıf (Scopus)

Özet

Asymmetric Mg (II) or Al (III) phthalocyanine (containing a COOH group and 3-pyridylsulfanyl units) was conjugated via an amide bond to amino functionalized magnetic nanoparticle (AIMN) to form MgPc-AIMN or AlPc-AIMN conjugate, and characterized. The photophysicochemical behaviour of the phthalocyanine–AIMN conjugates was investigated and compared to the asymmetric Pcs and to the simple mixture of Pc with AIMNs without a chemical bond, (MPc-AIMN (mixed)). The directed covalent linkage of AIMNs to the asymmetrical metallopthalocyanines afforded improvements in the singlet oxygen (Ф_Δ) and triplet state quantum yield (Ф_T) as well as singlet oxygen lifetimes for the MPcs–AIMN-linked conjugates compared to MPc-AIMN (mixed) and MPcs alone. The asymmetric phthalocyanines and their conjugates showed effective antimicrobial activity against Escherichia coli bacteria under illumination.

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	407-414
Sayfa sayısı	8
Dergi	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Hacim	193
DOI'lar	https://doi.org/10.1016/j.saa.2017.12.052
Yayın durumu	Yayınlandı - 15 Mar 2018

Bibliyografik not

Publisher Copyright:
© 2017 Elsevier B.V.

Finansman

This work was supported by the Department of Science and Technology (DST) and National Research Foundation (NRF), South Africa through DST/NRF South African Research Chairs Initiative for Professor of Medicinal Chemistry and Nanotechnology ( UID 62620 ), as well as Rhodes University . MI thanks FUNAAB for leave. YA thanks Istanbul Technical University, DPT and TUBITAK for leave. This work was supported by the Department of Science and Technology (DST) and National Research Foundation (NRF), South Africa through DST/NRF South African Research Chairs Initiative for Professor of Medicinal Chemistry and Nanotechnology (UID 62620), as well as Rhodes University. MI thanks FUNAAB for leave. YA thanks Istanbul Technical University, DPT and TUBITAK for leave.

Finansörler	Finansör numarası
DST/NRF	UID 62620
National Research Foundation
National Research Foundation
Rhodes University
Department of Science and Technology, Government of Kerala

Belgeye Erişim

10.1016/j.saa.2017.12.052

Diğer Dosyalar ve Linkler

Link to publication in Scopus

Alıntı Yap

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title = "Photophysicochemical behaviour and antimicrobial properties of monocarboxy Mg (II) and Al (III) phthalocyanine-magnetite conjugates",

abstract = "Asymmetric Mg (II) or Al (III) phthalocyanine (containing a COOH group and 3-pyridylsulfanyl units) was conjugated via an amide bond to amino functionalized magnetic nanoparticle (AIMN) to form MgPc-AIMN or AlPc-AIMN conjugate, and characterized. The photophysicochemical behaviour of the phthalocyanine–AIMN conjugates was investigated and compared to the asymmetric Pcs and to the simple mixture of Pc with AIMNs without a chemical bond, (MPc-AIMN (mixed)). The directed covalent linkage of AIMNs to the asymmetrical metallopthalocyanines afforded improvements in the singlet oxygen (ФΔ) and triplet state quantum yield (ФT) as well as singlet oxygen lifetimes for the MPcs–AIMN-linked conjugates compared to MPc-AIMN (mixed) and MPcs alone. The asymmetric phthalocyanines and their conjugates showed effective antimicrobial activity against Escherichia coli bacteria under illumination.",

keywords = "Asymmetric phthalocyanine, Magnetite, Nanoparticles, Photodynamic antimicrobial chemotherapy (PACT), Singlet oxygen",

author = "Idowu, \{Mopelola Abidemi\} and Solami Xego and Yasin Arslanoglu and John Mark and Edith Antunes and Tebello Nyokong",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2018",

month = mar,

day = "15",

doi = "10.1016/j.saa.2017.12.052",

language = "English",

volume = "193",

pages = "407--414",

journal = "Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy",

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TY - JOUR

T1 - Photophysicochemical behaviour and antimicrobial properties of monocarboxy Mg (II) and Al (III) phthalocyanine-magnetite conjugates

AU - Idowu, Mopelola Abidemi

AU - Xego, Solami

AU - Arslanoglu, Yasin

AU - Mark, John

AU - Antunes, Edith

AU - Nyokong, Tebello

PY - 2018/3/15

Y1 - 2018/3/15

N2 - Asymmetric Mg (II) or Al (III) phthalocyanine (containing a COOH group and 3-pyridylsulfanyl units) was conjugated via an amide bond to amino functionalized magnetic nanoparticle (AIMN) to form MgPc-AIMN or AlPc-AIMN conjugate, and characterized. The photophysicochemical behaviour of the phthalocyanine–AIMN conjugates was investigated and compared to the asymmetric Pcs and to the simple mixture of Pc with AIMNs without a chemical bond, (MPc-AIMN (mixed)). The directed covalent linkage of AIMNs to the asymmetrical metallopthalocyanines afforded improvements in the singlet oxygen (ФΔ) and triplet state quantum yield (ФT) as well as singlet oxygen lifetimes for the MPcs–AIMN-linked conjugates compared to MPc-AIMN (mixed) and MPcs alone. The asymmetric phthalocyanines and their conjugates showed effective antimicrobial activity against Escherichia coli bacteria under illumination.

AB - Asymmetric Mg (II) or Al (III) phthalocyanine (containing a COOH group and 3-pyridylsulfanyl units) was conjugated via an amide bond to amino functionalized magnetic nanoparticle (AIMN) to form MgPc-AIMN or AlPc-AIMN conjugate, and characterized. The photophysicochemical behaviour of the phthalocyanine–AIMN conjugates was investigated and compared to the asymmetric Pcs and to the simple mixture of Pc with AIMNs without a chemical bond, (MPc-AIMN (mixed)). The directed covalent linkage of AIMNs to the asymmetrical metallopthalocyanines afforded improvements in the singlet oxygen (ФΔ) and triplet state quantum yield (ФT) as well as singlet oxygen lifetimes for the MPcs–AIMN-linked conjugates compared to MPc-AIMN (mixed) and MPcs alone. The asymmetric phthalocyanines and their conjugates showed effective antimicrobial activity against Escherichia coli bacteria under illumination.

KW - Asymmetric phthalocyanine

KW - Magnetite

KW - Nanoparticles

KW - Photodynamic antimicrobial chemotherapy (PACT)

KW - Singlet oxygen

UR - https://www.scopus.com/pages/publications/85038845085

U2 - 10.1016/j.saa.2017.12.052

DO - 10.1016/j.saa.2017.12.052

M3 - Article

C2 - 29277071

AN - SCOPUS:85038845085

SN - 1386-1425

VL - 193

SP - 407

EP - 414

JO - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

JF - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

ER -

Photophysicochemical behaviour and antimicrobial properties of monocarboxy Mg (II) and Al (III) phthalocyanine-magnetite conjugates

Özet

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Belgeye Erişim

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