Photo-crosslinked PVA/PEI electrospun nanofiber membranes: Preparation and preliminary evaluation in virus clearance tests

Bihter Zeytuncu*, Melike Ürper, İsmail Koyuncu, Volodymyr V. Tarabara

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20 Atıf (Scopus)

Özet

We report on the preparation of electropositive nanofiber membranes by electrospinning with in situ photo-crosslinking and their preliminary evaluation in virus adsorption and removal tests. Poly(vinyl alcohol) (PVA) and polyethyleneimine (PEI) were modified with glycidyl methacrylate, to form an acrylated crosslinked polymer (a-PVA/a-PEI) upon UV exposure during the electrospinning process. The a-PVA/a-PEI nanofibers were electrospun on a non-woven polyester support to form an electropositive (ζ = 7 mV at pH 7.4) and hydrophilic (θw∼53°) membrane with the mean pore size of 0.48 μm. The microfilter had the specific permeate flux of ∼6.9 · 104 L/(m2·h·bar), comparable with that of commercially available membranes of similar nominal pore sizes. Adsorption of the negatively charged and hydrophilic bacteriophage MS2 (d∼27 nm) onto the membrane followed Freundlich isotherm and could be classified as favorable with the average adsorption intensity n-1∼0.91. The 99% retention of MS2 in flow-through virus clearance tests was attributed to adsorption and was likely controlled by the limited detention time within the membrane.

Orijinal dilİngilizce
Sayfa (başlangıç-bitiş)432-438
Sayfa sayısı7
DergiSeparation and Purification Technology
Hacim197
DOI'lar
Yayın durumuYayınlandı - 31 May 2018

Bibliyografik not

Publisher Copyright:
© 2018 Elsevier B.V.

Finansman

This material is based upon work supported in part by The Scientific and Technological Research Council of Turkey (TUBITAK) BIDEB-2219 Postdoctoral Research Scholarship Program under grant number 1059B191401279 to Dr. Bihter Zeytuncu and in part by the National Science Foundation Partnerships for International Education and Research Program under Grant IIA-1243433 . The authors thank Ms. Abigail Vanderberg and Ms. Amy Albin (Center for Advanced Microscopy, MSU) for their assistance with electron microscopy imaging. We are grateful to Dr. Merlin L. Bruening (Department of Chemistry, MSU) for providing access to the FTIR spectrometer and Dr. Scott Calabrese Barton (Department of Chemical Engineering and Materials Science, MSU) for letting us use the electrospinning system in his laboratory. We also thank two anonymous reviewers for their insightful criticism and suggestions. Appendix A

FinansörlerFinansör numarası
National Science Foundation Partnerships for International Education and Research ProgramIIA-1243433
Scientific and Technological Research Council of Turkey
TUBITAK1059B191401279

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