Photo-crosslinkable chitosan and gelatin-based nanohybrid bioinks for extrusion-based 3D-bioprinting

Elif Yuce-Erarslan, Rumeysa Tutar, Burçin İzbudak, Emine Alarçin, Banu Kocaaga, F. Seniha Guner, Serkan Emik, Ayca Bal-Ozturk*

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11 Atıf (Scopus)

Özet

In the last decade, 3D-bioprinting has attracted attention due to its capability to produce complex scaffolds. The selection of suitable biomaterials for the bioink design is very important for the success of 3D-bioprinting. In this study, chitosan and gelatin were chemically modified into methacrylated chitosan (ChiMA) and methacrylated gelatin (GelMA) with the methacrylic anhydride in order to obtain crosslinking points on the polymeric backbone. The eligible bioinks were formulated with the layered double hydroxide nanoparticles (LDHs). The effect of changing the amount of LDHs on the printability of the bioinks was evaluated by using rheological analysis and printability test with the extrusion-based 3D-bioprinting. The bioinks were crosslinked under UV light. Mechanical, swelling, degradation properties, and cell-adhesion behaviors of the obtained ChiMA/GelMA nanohybrid scaffolds containing LDHs were investigated. Based on the rheology and the printing results, ChiMA/GelMA nanohybrid scaffold containing 5% LDHs (ChiMA-G5) was found to be the optimal bioink. Notably, compression strength, elongation at break, and elastic modulus of ChiMA-G5 scaffold were higher than neat and other ChiMA/GelMA scaffolds. In vitro cell culture studies showed that LDHs do not have any negative effects. These findings indicate that the developed ChiMA-G5 bioink has great potential as a bioink to utilize for tissue engineering applications.

Orijinal dilİngilizce
Sayfa (başlangıç-bitiş)1-12
Sayfa sayısı12
DergiInternational Journal of Polymeric Materials and Polymeric Biomaterials
Hacim72
Basın numarası1
DOI'lar
Yayın durumuYayınlandı - 2023

Bibliyografik not

Publisher Copyright:
© 2021 Taylor & Francis Group, LLC.

Finansman

The present work was financially supported by the Scientific and Technological Research Council of Turkey (TÜBİTAK) under project number 118S549.

FinansörlerFinansör numarası
Türkiye Bilimsel ve Teknolojik Araştırma Kurumu118S549

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