Pharmacological Properties of Genista sagittalis L. (Fabaceae) Grown in Turkey

Pelin Şenel; Bleda Can Sadıkoğulları; Elif Çepni Yüzbaşıoğlu; Gülnur Mertoğlu Elmas; Dilek Oral; Ayşegül Gölcü; Ayşe Daut Özdemir

doi:10.22146/ijc.79477

Pharmacological Properties of Genista sagittalis L. (Fabaceae) Grown in Turkey

Pelin Şenel
, Bleda Can Sadıkoğulları
, Elif Çepni Yüzbaşıoğlu
, Gülnur Mertoğlu Elmas
, Dilek Oral
, Ayşegül Gölcü^*
, Ayşe Daut Özdemir^*

^*Bu çalışma için yazışmadan sorumlu yazar

Kimya Bölümü

Araştırma sonucu: Dergiye katkı › Makale › bilirkişi

Özet

The genus Genista L. (Family: Fabaceae) is a plant having several traditional uses for treating common ailments such as diabetes, ulcer, and respiratory diseases. In this current study, the composition of essential oil and the biological activities of Genista sagittalis L. (Fabaceae) from Kocaeli: Yuvacık Dam Basin have been studied. A total of fourteen components were identified in the essential oil. The identified compounds belonged to straight-chain alkane, aromatic ether, and terpenoid derivatives. The antibacterial activity analyses demonstrated that G. sagittalis flower extract only had low activity against P. mirabilis and P. aeruginosa with MICs 1 to 2 mg/mL, as the peduncle extract showed strong anti-QS activity at 1.3 mg/mL. To the best of our knowledge, the current work is the first to report the antimicrobial and anti-quorum sensing activity of G. sagittalis growing in Turkey. Double-stranded DNA binding affinity investigations of the flower and peduncle ethanol extracts indicate that there are interactions with double-stranded DNA and related binding constants (K_b) were found as 1.97 × 10³ ± 0.37 and 3.68 × 10² ± 0.44 for the flower and peduncle extract, respectively.

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	681-691
Sayfa sayısı	11
Dergi	Indonesian Journal of Chemistry
Hacim	23
Basın numarası	3
DOI'lar	https://doi.org/10.22146/ijc.79477
Yayın durumu	Yayınlandı - 2023

Bibliyografik not

Publisher Copyright:
© 2023, Gadjah Mada University. All rights reserved.

Finansman

The authors wish to thank to Istanbul Technical University, Faculty of Sciences and Letters, Department of Chemistry for experimental conditions (Lab L-105 and L2-111 belonging to Prof. Gölcü and Dr. Özdemir respectively) and to Dr. Kübra Erkan Türkmen from Hacettepe University for providing the bacterial strain CV12472. The authors would like to thank the support of the grant of Istanbul Technical University (Scientific Research Projects Unit) under the THD-2023-44771 project. The authors wish to thank to Istanbul Technical University, Faculty of Sciences and Letters, Department of Chemistry for experimental conditions (Lab L-105 and L2-111 belonging to Prof. Gö ̈ and Dr. Özdemir respectively) and to Dr. Kübra Erkan Türkmen from Hacettepe University for providing the bacterial strain CV12472. The authors would like to thank the support of the grant of Istanbul Technical University (Scientific Research Projects Unit) under the THD-2023-44771 project.

Finansörler	Finansör numarası
Hacettepe Üniversitesi
Istanbul Teknik Üniversitesi	THD-2023-44771

BM SKH

Bu sonuç, aşağıdaki Sürdürülebilir Kalkınma Hedefine/Hedeflerine katkıda bulunur

SKH 3 Sağlık ve Kaliteli Yaşam

Belgeye Erişim

10.22146/ijc.79477

Diğer Dosyalar ve Linkler

Link to publication in Scopus

Alıntı Yap

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title = "Pharmacological Properties of Genista sagittalis L. (Fabaceae) Grown in Turkey",

abstract = "The genus Genista L. (Family: Fabaceae) is a plant having several traditional uses for treating common ailments such as diabetes, ulcer, and respiratory diseases. In this current study, the composition of essential oil and the biological activities of Genista sagittalis L. (Fabaceae) from Kocaeli: Yuvacık Dam Basin have been studied. A total of fourteen components were identified in the essential oil. The identified compounds belonged to straight-chain alkane, aromatic ether, and terpenoid derivatives. The antibacterial activity analyses demonstrated that G. sagittalis flower extract only had low activity against P. mirabilis and P. aeruginosa with MICs 1 to 2 mg/mL, as the peduncle extract showed strong anti-QS activity at 1.3 mg/mL. To the best of our knowledge, the current work is the first to report the antimicrobial and anti-quorum sensing activity of G. sagittalis growing in Turkey. Double-stranded DNA binding affinity investigations of the flower and peduncle ethanol extracts indicate that there are interactions with double-stranded DNA and related binding constants (Kb) were found as 1.97 × 103 ± 0.37 and 3.68 × 102 ± 0.44 for the flower and peduncle extract, respectively.",

keywords = "DNA binding, Fabaceae, Genista sagittalis, anti-quorum sensing, antibacterial, plant extracts",

author = "Pelin {\c S}enel and Sadıkoğulları, \{Bleda Can\} and Y{\"u}zba{\c s}ıoğlu, \{Elif {\c C}epni\} and Elmas, \{G{\"u}lnur Mertoğlu\} and Dilek Oral and Ay{\c s}eg{\"u}l G{\"o}lc{\"u} and {\"O}zdemir, \{Ay{\c s}e Daut\}",

year = "2023",

doi = "10.22146/ijc.79477",

language = "English",

volume = "23",

pages = "681--691",

journal = "Indonesian Journal of Chemistry",

issn = "1411-9420",

publisher = "Gadjah Mada University",

number = "3",

}

TY - JOUR

T1 - Pharmacological Properties of Genista sagittalis L. (Fabaceae) Grown in Turkey

AU - Şenel, Pelin

AU - Sadıkoğulları, Bleda Can

AU - Yüzbaşıoğlu, Elif Çepni

AU - Elmas, Gülnur Mertoğlu

AU - Oral, Dilek

AU - Gölcü, Ayşegül

AU - Özdemir, Ayşe Daut

PY - 2023

Y1 - 2023

N2 - The genus Genista L. (Family: Fabaceae) is a plant having several traditional uses for treating common ailments such as diabetes, ulcer, and respiratory diseases. In this current study, the composition of essential oil and the biological activities of Genista sagittalis L. (Fabaceae) from Kocaeli: Yuvacık Dam Basin have been studied. A total of fourteen components were identified in the essential oil. The identified compounds belonged to straight-chain alkane, aromatic ether, and terpenoid derivatives. The antibacterial activity analyses demonstrated that G. sagittalis flower extract only had low activity against P. mirabilis and P. aeruginosa with MICs 1 to 2 mg/mL, as the peduncle extract showed strong anti-QS activity at 1.3 mg/mL. To the best of our knowledge, the current work is the first to report the antimicrobial and anti-quorum sensing activity of G. sagittalis growing in Turkey. Double-stranded DNA binding affinity investigations of the flower and peduncle ethanol extracts indicate that there are interactions with double-stranded DNA and related binding constants (Kb) were found as 1.97 × 103 ± 0.37 and 3.68 × 102 ± 0.44 for the flower and peduncle extract, respectively.

AB - The genus Genista L. (Family: Fabaceae) is a plant having several traditional uses for treating common ailments such as diabetes, ulcer, and respiratory diseases. In this current study, the composition of essential oil and the biological activities of Genista sagittalis L. (Fabaceae) from Kocaeli: Yuvacık Dam Basin have been studied. A total of fourteen components were identified in the essential oil. The identified compounds belonged to straight-chain alkane, aromatic ether, and terpenoid derivatives. The antibacterial activity analyses demonstrated that G. sagittalis flower extract only had low activity against P. mirabilis and P. aeruginosa with MICs 1 to 2 mg/mL, as the peduncle extract showed strong anti-QS activity at 1.3 mg/mL. To the best of our knowledge, the current work is the first to report the antimicrobial and anti-quorum sensing activity of G. sagittalis growing in Turkey. Double-stranded DNA binding affinity investigations of the flower and peduncle ethanol extracts indicate that there are interactions with double-stranded DNA and related binding constants (Kb) were found as 1.97 × 103 ± 0.37 and 3.68 × 102 ± 0.44 for the flower and peduncle extract, respectively.

KW - DNA binding

KW - Fabaceae

KW - Genista sagittalis

KW - anti-quorum sensing

KW - antibacterial

KW - plant extracts

UR - https://www.scopus.com/pages/publications/85163214362

U2 - 10.22146/ijc.79477

DO - 10.22146/ijc.79477

M3 - Article

AN - SCOPUS:85163214362

SN - 1411-9420

VL - 23

SP - 681

EP - 691

JO - Indonesian Journal of Chemistry

JF - Indonesian Journal of Chemistry

IS - 3

ER -

Pharmacological Properties of Genista sagittalis L. (Fabaceae) Grown in Turkey

Özet

Bibliyografik not

Finansman

BM SKH

Belgeye Erişim

Diğer Dosyalar ve Linkler

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