Patient-Specific In-Silico Hemodynamic Analysis of the Anomalous Aortic Origin of the Coronary Artery (AAOCA)

Hacer Duzman; Reza Daryani; Emre Cenk Ersan; Mustafa Serdar Celebi

doi:10.1007/978-3-031-62520-6_64

Patient-Specific In-Silico Hemodynamic Analysis of the Anomalous Aortic Origin of the Coronary Artery (AAOCA)

Hacer Duzman^*, Reza Daryani, Emre Cenk Ersan, Mustafa Serdar Celebi

^*Bu çalışma için yazışmadan sorumlu yazar

Bilişim Enstitüsü

Istanbul Technical University

Araştırma sonucu: ???type-name??? › Konferans katkısı › bilirkişi

Özet

Anomalous aortic origin of the coronary artery (AAOCA) can lead to ischemia and abrupt mortality. This study investigates the hemodynamic effects of AAOCA with various take-off angles and ostium shapes using computational fluid dynamics (CFD) simulations. The research utilizes patient-specific coronary artery geometry reconstructed from a computed tomography coronary angiogram (CTCA), focusing on the left coronary artery (LCA). The results indicate that as the take-off angle of the LCA narrows, the ostium shape becomes more horizontally elliptical, leading to increased wall shear stress (WSS) and WSS-based indices such as time-averaged wall shear stress (TAWSS) and transverse wall shear stress (transWSS). Furthermore, the analysis of fractional flow reserve (FFR) provides valuable insights into the physiological significance. These findings highlight the potential risk factors associated with AAOCA and emphasize the importance of understanding how hemodynamic changes may contribute to coronary artery disease and clinical management.

Orijinal dil	İngilizce
Ana bilgisayar yayını başlığı	Advances in Digital Health and Medical Bioengineering - Proceedings of the 11th International Conference on E-Health and Bioengineering, EHB-2023 - Volume 2
Ana bilgisayar yayını alt yazısı	Health Technology Assessment, Biomedical Signal Processing, Medicine and Informatics
Editörler	Hariton-Nicolae Costin, Ratko Magjarević, Gladiola Gabriela Petroiu
Yayınlayan	Springer Science and Business Media Deutschland GmbH
Sayfalar	574-582
Sayfa sayısı	9
ISBN (Basılı)	9783031625190
DOI'lar	https://doi.org/10.1007/978-3-031-62520-6_64
Yayın durumu	Yayınlandı - 2024
Etkinlik	11th International Conference on E-Health and Bioengineering, EHB 2023 - Bucharest, Romania Süre: 9 Kas 2023 → 10 Kas 2023

Yayın serisi

Adı	IFMBE Proceedings
Hacim	110
ISSN (Basılı)	1680-0737
ISSN (Elektronik)	1433-9277

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???event.eventtypes.event.conference???	11th International Conference on E-Health and Bioengineering, EHB 2023
Ülke/Bölge	Romania
Şehir	Bucharest
Periyot	9/11/23 → 10/11/23

Bibliyografik not

Publisher Copyright:
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.

BM SKH

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Belgeye Erişim

10.1007/978-3-031-62520-6_64

Diğer Dosyalar ve Linkler

Link to publication in Scopus

Alıntı Yap

Duzman, H., Daryani, R., Ersan, E. C., & Celebi, M. S. (2024). Patient-Specific In-Silico Hemodynamic Analysis of the Anomalous Aortic Origin of the Coronary Artery (AAOCA). In H.-N. Costin, R. Magjarević, & G. G. Petroiu (Eds.), Advances in Digital Health and Medical Bioengineering - Proceedings of the 11th International Conference on E-Health and Bioengineering, EHB-2023 - Volume 2: Health Technology Assessment, Biomedical Signal Processing, Medicine and Informatics (pp. 574-582). (IFMBE Proceedings; Hac. 110). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-3-031-62520-6_64

Duzman, Hacer ; Daryani, Reza ; Ersan, Emre Cenk et al. / Patient-Specific In-Silico Hemodynamic Analysis of the Anomalous Aortic Origin of the Coronary Artery (AAOCA). Advances in Digital Health and Medical Bioengineering - Proceedings of the 11th International Conference on E-Health and Bioengineering, EHB-2023 - Volume 2: Health Technology Assessment, Biomedical Signal Processing, Medicine and Informatics. editör / Hariton-Nicolae Costin ; Ratko Magjarević ; Gladiola Gabriela Petroiu. Springer Science and Business Media Deutschland GmbH, 2024. pp. 574-582 (IFMBE Proceedings).

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title = "Patient-Specific In-Silico Hemodynamic Analysis of the Anomalous Aortic Origin of the Coronary Artery (AAOCA)",

abstract = "Anomalous aortic origin of the coronary artery (AAOCA) can lead to ischemia and abrupt mortality. This study investigates the hemodynamic effects of AAOCA with various take-off angles and ostium shapes using computational fluid dynamics (CFD) simulations. The research utilizes patient-specific coronary artery geometry reconstructed from a computed tomography coronary angiogram (CTCA), focusing on the left coronary artery (LCA). The results indicate that as the take-off angle of the LCA narrows, the ostium shape becomes more horizontally elliptical, leading to increased wall shear stress (WSS) and WSS-based indices such as time-averaged wall shear stress (TAWSS) and transverse wall shear stress (transWSS). Furthermore, the analysis of fractional flow reserve (FFR) provides valuable insights into the physiological significance. These findings highlight the potential risk factors associated with AAOCA and emphasize the importance of understanding how hemodynamic changes may contribute to coronary artery disease and clinical management.",

keywords = "AAOCA, Hemodynamics, Ostium, Take-off angle",

author = "Hacer Duzman and Reza Daryani and Ersan, {Emre Cenk} and Celebi, {Mustafa Serdar}",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.; 11th International Conference on E-Health and Bioengineering, EHB 2023 ; Conference date: 09-11-2023 Through 10-11-2023",

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Duzman, H, Daryani, R, Ersan, EC & Celebi, MS 2024, Patient-Specific In-Silico Hemodynamic Analysis of the Anomalous Aortic Origin of the Coronary Artery (AAOCA). in H-N Costin, R Magjarević & GG Petroiu (eds), Advances in Digital Health and Medical Bioengineering - Proceedings of the 11th International Conference on E-Health and Bioengineering, EHB-2023 - Volume 2: Health Technology Assessment, Biomedical Signal Processing, Medicine and Informatics. IFMBE Proceedings, hac. 110, Springer Science and Business Media Deutschland GmbH, pp. 574-582, 11th International Conference on E-Health and Bioengineering, EHB 2023, Bucharest, Romania, 9/11/23. https://doi.org/10.1007/978-3-031-62520-6_64

Patient-Specific In-Silico Hemodynamic Analysis of the Anomalous Aortic Origin of the Coronary Artery (AAOCA). / Duzman, Hacer; Daryani, Reza; Ersan, Emre Cenk et al.
Advances in Digital Health and Medical Bioengineering - Proceedings of the 11th International Conference on E-Health and Bioengineering, EHB-2023 - Volume 2: Health Technology Assessment, Biomedical Signal Processing, Medicine and Informatics. ed. / Hariton-Nicolae Costin; Ratko Magjarević; Gladiola Gabriela Petroiu. Springer Science and Business Media Deutschland GmbH, 2024. p. 574-582 (IFMBE Proceedings; Hac. 110).

Araştırma sonucu: ???type-name??? › Konferans katkısı › bilirkişi

TY - GEN

T1 - Patient-Specific In-Silico Hemodynamic Analysis of the Anomalous Aortic Origin of the Coronary Artery (AAOCA)

AU - Duzman, Hacer

AU - Daryani, Reza

AU - Ersan, Emre Cenk

AU - Celebi, Mustafa Serdar

N1 - Publisher Copyright: © The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.

PY - 2024

Y1 - 2024

N2 - Anomalous aortic origin of the coronary artery (AAOCA) can lead to ischemia and abrupt mortality. This study investigates the hemodynamic effects of AAOCA with various take-off angles and ostium shapes using computational fluid dynamics (CFD) simulations. The research utilizes patient-specific coronary artery geometry reconstructed from a computed tomography coronary angiogram (CTCA), focusing on the left coronary artery (LCA). The results indicate that as the take-off angle of the LCA narrows, the ostium shape becomes more horizontally elliptical, leading to increased wall shear stress (WSS) and WSS-based indices such as time-averaged wall shear stress (TAWSS) and transverse wall shear stress (transWSS). Furthermore, the analysis of fractional flow reserve (FFR) provides valuable insights into the physiological significance. These findings highlight the potential risk factors associated with AAOCA and emphasize the importance of understanding how hemodynamic changes may contribute to coronary artery disease and clinical management.

AB - Anomalous aortic origin of the coronary artery (AAOCA) can lead to ischemia and abrupt mortality. This study investigates the hemodynamic effects of AAOCA with various take-off angles and ostium shapes using computational fluid dynamics (CFD) simulations. The research utilizes patient-specific coronary artery geometry reconstructed from a computed tomography coronary angiogram (CTCA), focusing on the left coronary artery (LCA). The results indicate that as the take-off angle of the LCA narrows, the ostium shape becomes more horizontally elliptical, leading to increased wall shear stress (WSS) and WSS-based indices such as time-averaged wall shear stress (TAWSS) and transverse wall shear stress (transWSS). Furthermore, the analysis of fractional flow reserve (FFR) provides valuable insights into the physiological significance. These findings highlight the potential risk factors associated with AAOCA and emphasize the importance of understanding how hemodynamic changes may contribute to coronary artery disease and clinical management.

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KW - Hemodynamics

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KW - Take-off angle

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Duzman H, Daryani R, Ersan EC, Celebi MS. Patient-Specific In-Silico Hemodynamic Analysis of the Anomalous Aortic Origin of the Coronary Artery (AAOCA). In Costin HN, Magjarević R, Petroiu GG, editörler, Advances in Digital Health and Medical Bioengineering - Proceedings of the 11th International Conference on E-Health and Bioengineering, EHB-2023 - Volume 2: Health Technology Assessment, Biomedical Signal Processing, Medicine and Informatics. Springer Science and Business Media Deutschland GmbH. 2024. p. 574-582. (IFMBE Proceedings). doi: 10.1007/978-3-031-62520-6_64

Patient-Specific In-Silico Hemodynamic Analysis of the Anomalous Aortic Origin of the Coronary Artery (AAOCA)

Özet

Yayın serisi

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