Ovarian antiproliferative activity directed isolation of triterpenoids from fruits of Eucalyptus camaldulensis Dehnh

Gülaçti Topu; Gönül Yapar; Zeynep Türkmen; Ahmet Ceyhan Gören; Sevil Öksüz; Jennifer K. Schilling; David G.I. Kingston

doi:10.1016/j.phytol.2011.05.002

Ovarian antiproliferative activity directed isolation of triterpenoids from fruits of Eucalyptus camaldulensis Dehnh

Gülaçti Topu^*
, Gönül Yapar
, Zeynep Türkmen
, Ahmet Ceyhan Gören
, Sevil Öksüz
, Jennifer K. Schilling
, David G.I. Kingston

^*Bu çalışma için yazışmadan sorumlu yazar

Kimya Bölümü

Istanbul Technical University
Istanbul University
Scientific and Technological Research Council of Turkey
Virginia Polytechnic Institute and State University

Araştırma sonucu: Dergiye katkı › Makale › bilirkişi

28 Atıf (Scopus)

Özet

Bioassay-guided fractionation of a methanol extract of the fruits of Eucalyptus camaldulensis Dehnh. with moderate antiproliferative activity afforded the new triterpene, 3β-acetoxy-urs-11,13(18)-dien-28-oic acid (1) along with the known triterpenoids 3β-hydroxy-urs-11-en-28,13β-olide (2), 3β-acetoxy-urs-11-en-28,13β-olide (3), 3-acetylbetulinic acid (4), oleanolic acid (5), ursolic acid (6), β-amyrin acetate (7), β-sitosterol (8) and sitosterol 3-O-β-D-glucopyranoside (9). Their structures were established on the basis of analysis of their ¹H and ¹³C NMR, APT, gHSQC, gHMBC, UV, IR and mass spectral data. The tested triterpenoids (1-7) exhibited weak-moderate antiproliferative activity against the A2780 human ovarian cancer cell line.

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	421-425
Sayfa sayısı	5
Dergi	Phytochemistry Letters
Hacim	4
Basın numarası	4
DOI'lar	https://doi.org/10.1016/j.phytol.2011.05.002
Yayın durumu	Yayınlandı - Ara 2011

Finansman

The authors thank TUBITAK and NSF for support of this work with the grant TBAG-U53/NSF-INT-0002071 .

Finansörler	Finansör numarası
TUBITAK	TBAG-U53/NSF-INT-0002071

BM SKH

Bu sonuç, aşağıdaki Sürdürülebilir Kalkınma Hedefine/Hedeflerine katkıda bulunur

SKH 3 Sağlık ve Kaliteli Yaşam

Belgeye Erişim

10.1016/j.phytol.2011.05.002

Diğer Dosyalar ve Linkler

Link to publication in Scopus

Alıntı Yap

@article{ffc16286e8164947886023439453e134,

title = "Ovarian antiproliferative activity directed isolation of triterpenoids from fruits of Eucalyptus camaldulensis Dehnh",

abstract = "Bioassay-guided fractionation of a methanol extract of the fruits of Eucalyptus camaldulensis Dehnh. with moderate antiproliferative activity afforded the new triterpene, 3β-acetoxy-urs-11,13(18)-dien-28-oic acid (1) along with the known triterpenoids 3β-hydroxy-urs-11-en-28,13β-olide (2), 3β-acetoxy-urs-11-en-28,13β-olide (3), 3-acetylbetulinic acid (4), oleanolic acid (5), ursolic acid (6), β-amyrin acetate (7), β-sitosterol (8) and sitosterol 3-O-β-D-glucopyranoside (9). Their structures were established on the basis of analysis of their 1H and 13C NMR, APT, gHSQC, gHMBC, UV, IR and mass spectral data. The tested triterpenoids (1-7) exhibited weak-moderate antiproliferative activity against the A2780 human ovarian cancer cell line.",

keywords = "3β-acetoxy-urs-11, 13(18)-dien-28-oic acid (eucamaldulenoic acid), A2780 ovarian antiproliferative activity, Eucalyptus camaldulensis, Myrtaceae, Triterpenoids",

author = "G{\"u}la{\c c}ti Topu and G{\"o}n{\"u}l Yapar and Zeynep T{\"u}rkmen and G{\"o}ren, \{Ahmet Ceyhan\} and Sevil {\"O}ks{\"u}z and Schilling, \{Jennifer K.\} and Kingston, \{David G.I.\}",

year = "2011",

month = dec,

doi = "10.1016/j.phytol.2011.05.002",

language = "English",

volume = "4",

pages = "421--425",

journal = "Phytochemistry Letters",

issn = "1874-3900",

publisher = "Elsevier Ltd",

number = "4",

}

TY - JOUR

T1 - Ovarian antiproliferative activity directed isolation of triterpenoids from fruits of Eucalyptus camaldulensis Dehnh

AU - Topu, Gülaçti

AU - Yapar, Gönül

AU - Türkmen, Zeynep

AU - Gören, Ahmet Ceyhan

AU - Öksüz, Sevil

AU - Schilling, Jennifer K.

AU - Kingston, David G.I.

PY - 2011/12

Y1 - 2011/12

N2 - Bioassay-guided fractionation of a methanol extract of the fruits of Eucalyptus camaldulensis Dehnh. with moderate antiproliferative activity afforded the new triterpene, 3β-acetoxy-urs-11,13(18)-dien-28-oic acid (1) along with the known triterpenoids 3β-hydroxy-urs-11-en-28,13β-olide (2), 3β-acetoxy-urs-11-en-28,13β-olide (3), 3-acetylbetulinic acid (4), oleanolic acid (5), ursolic acid (6), β-amyrin acetate (7), β-sitosterol (8) and sitosterol 3-O-β-D-glucopyranoside (9). Their structures were established on the basis of analysis of their 1H and 13C NMR, APT, gHSQC, gHMBC, UV, IR and mass spectral data. The tested triterpenoids (1-7) exhibited weak-moderate antiproliferative activity against the A2780 human ovarian cancer cell line.

AB - Bioassay-guided fractionation of a methanol extract of the fruits of Eucalyptus camaldulensis Dehnh. with moderate antiproliferative activity afforded the new triterpene, 3β-acetoxy-urs-11,13(18)-dien-28-oic acid (1) along with the known triterpenoids 3β-hydroxy-urs-11-en-28,13β-olide (2), 3β-acetoxy-urs-11-en-28,13β-olide (3), 3-acetylbetulinic acid (4), oleanolic acid (5), ursolic acid (6), β-amyrin acetate (7), β-sitosterol (8) and sitosterol 3-O-β-D-glucopyranoside (9). Their structures were established on the basis of analysis of their 1H and 13C NMR, APT, gHSQC, gHMBC, UV, IR and mass spectral data. The tested triterpenoids (1-7) exhibited weak-moderate antiproliferative activity against the A2780 human ovarian cancer cell line.

KW - 3β-acetoxy-urs-11, 13(18)-dien-28-oic acid (eucamaldulenoic acid)

KW - A2780 ovarian antiproliferative activity

KW - Eucalyptus camaldulensis

KW - Myrtaceae

KW - Triterpenoids

UR - https://www.scopus.com/pages/publications/81855183247

U2 - 10.1016/j.phytol.2011.05.002

DO - 10.1016/j.phytol.2011.05.002

M3 - Article

AN - SCOPUS:81855183247

SN - 1874-3900

VL - 4

SP - 421

EP - 425

JO - Phytochemistry Letters

JF - Phytochemistry Letters

IS - 4

ER -

Ovarian antiproliferative activity directed isolation of triterpenoids from fruits of Eucalyptus camaldulensis Dehnh

Özet

Finansman

BM SKH

Belgeye Erişim

Diğer Dosyalar ve Linkler

Parmak izi

Alıntı Yap