Orthogonal Multiple Click Reactions for Macromolecular Design

In this article, we first examine the classical click reactions and new members (or candidates) to the click chemistry family involving multicomponent reactions (MCRs) utilized in synthetic polymer chemistry. The pros and cons of MCRs are described in the way of click chemistry philosophy. Subsequently, updated click combinations implemented to the synthesis of macromolecular structures are presented in two tables starting from double toward multiple. Moreover, combinations of click reactions with MCRs are presented comprehensively.