Optimization of PLGA-DSPE hybrid nano-micelles with enhanced hydrophobic capacity for curcumin delivery

Fatmanur Babalı Balıbey, Fatemeh Bahadori*, Gamze Ergin Kizilcay, Adem Tekin, Ebru Kanimdan, Abdurrahim Kocyigit*

*Bu çalışma için yazışmadan sorumlu yazar

Araştırma sonucu: Dergiye katkıMakalebilirkişi

1 Atıf (Scopus)

Özet

Poly (D, L Lactic-co-Glycolic acid) (PLGA) is an FDA-approved polymer. It is distinguished from other biocompatible polymers by its feasibility of production and safety for intravenous cancer tumor targeting. Curcumin (CUR) is a natural molecule with versatile bioactivities including inhibiting the nuclear Factor kappa B (Nf-kB) levels in cancer cells, increased by chemotherapy agents. Our group previously reported a successful decrease in the p65 (RelA) subunit of Nf-kB using 125 µg/ml CUR loaded into PLGA nano-micelles. However, this amount was insufficient to reduce all Nf-kB subunits. This study aimed to increase the hydrophobic capacity of PLGA toward CUR using 1,2-Distearoyl-sn-glycerol-3-phosphoethanolamine (DSPE), an FDA-approved phospholipid. PLGA-DSPE hybrid nano-micelles (HNM) were prepared using two different methods, oil-in-water (OiWa) and film preparation-rehydration (FiRe). The encapsulated CUR was successfully increased to 250 µg/ml using the FiRe method. Physicochemical characterization of CUR-loaded HNM was performed using DLS FT-IR, DSC, and HPLC. In HNM with a size of 156.6 nm, DSPE, incorporated with all functional groups of PLGA, and CUR was trapped in the core of this structure. The release profile of CUR was suitable for targeted cancer therapy and the Encapsulation Efficacy was 92%.

Orijinal dilİngilizce
Sayfa (başlangıç-bitiş)843-855
Sayfa sayısı13
DergiPharmaceutical Development and Technology
Hacim28
Basın numarası9
DOI'lar
Yayın durumuYayınlandı - 2023

Bibliyografik not

Publisher Copyright:
© 2023 Informa UK Limited, trading as Taylor & Francis Group.

Finansman

This work was supported by a research fund of Bezmialem University, Projects No: 20201206.

FinansörlerFinansör numarası
Bezmialem University20201206

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