New metal-based drugs: spectral, electrochemical, DNA-binding and anticancer activity properties

Mustafa Çeşme; Harun Muslu; Mehmet Tumer; Özge Güngör; Mine Altunbek; Mustafa Culha; Aysegul Golcu

doi:10.1080/24701556.2021.2015385

New metal-based drugs: spectral, electrochemical, DNA-binding and anticancer activity properties

Mustafa Çeşme^*, Harun Muslu, Mehmet Tumer, Özge Güngör, Mine Altunbek, Mustafa Culha, Aysegul Golcu

^*Bu çalışma için yazışmadan sorumlu yazar

Kimya Bölümü

Araştırma sonucu: Dergiye katkı › Makale › bilirkişi

Özet

The coordination compounds of antineoplastic chemotherapy drug of dacarbazine (DAC) with Zn(II) ([Zn(DAC)₂] 3H₂O; NGDCM1) and Cu(II) ([Cu(DAC)ClH₂O]; NGDCM2) were synthesized and characterized using analytical and spectroscopic techniques. The electrochemical behaviors of the obtained new compounds and the starting active substance DAC were examined in detail. The interaction of all compounds with fish sperm double-stranded deoxyribonucleic acid (FSdsDNA) was investigated by measuring their binding constant (K_b) to FSdsDNA. Also, the competitive binding fluorescence spectroscopy studies with ethidium bromide (EtBr) were carried out. Furthermore, both compound’s anticancer activities were investigated on human lung cancer (A549) cells, and their effects were compared to other metals possessing antineoplastic drugs, including oxaliplatin and cisplatin.

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	165-176
Sayfa sayısı	12
Dergi	Inorganic and Nano-Metal Chemistry
Hacim	54
Basın numarası	2
DOI'lar	https://doi.org/10.1080/24701556.2021.2015385
Yayın durumu	Yayınlandı - 2024

Bibliyografik not

Publisher Copyright:
© 2021 Taylor & Francis Group, LLC.

Finansman

The authors wish to thank TUBITAK (Project No: 112T721, COST/CM1105) for the financial supports.

Finansörler	Finansör numarası
TUBITAK	112T721, COST/CM1105

BM SKH

Bu sonuç, aşağıdaki Sürdürülebilir Kalkınma Hedefine/Hedeflerine katkıda bulunur

Belgeye Erişim

10.1080/24701556.2021.2015385

Diğer Dosyalar ve Linkler

Link to publication in Scopus

Alıntı Yap

@article{709fb0039a6e42f693acfa16c2e5eec5,

title = "New metal-based drugs: spectral, electrochemical, DNA-binding and anticancer activity properties",

abstract = "The coordination compounds of antineoplastic chemotherapy drug of dacarbazine (DAC) with Zn(II) ([Zn(DAC)2] 3H2O; NGDCM1) and Cu(II) ([Cu(DAC)ClH2O]; NGDCM2) were synthesized and characterized using analytical and spectroscopic techniques. The electrochemical behaviors of the obtained new compounds and the starting active substance DAC were examined in detail. The interaction of all compounds with fish sperm double-stranded deoxyribonucleic acid (FSdsDNA) was investigated by measuring their binding constant (Kb) to FSdsDNA. Also, the competitive binding fluorescence spectroscopy studies with ethidium bromide (EtBr) were carried out. Furthermore, both compound{\textquoteright}s anticancer activities were investigated on human lung cancer (A549) cells, and their effects were compared to other metals possessing antineoplastic drugs, including oxaliplatin and cisplatin.",

keywords = "DNA binding, Metal-based drugs, antineoplastic, dacarbazine",

author = "Mustafa {\c C}e{\c s}me and Harun Muslu and Mehmet Tumer and {\"O}zge G{\"u}ng{\"o}r and Mine Altunbek and Mustafa Culha and Aysegul Golcu",

note = "Publisher Copyright: {\textcopyright} 2021 Taylor & Francis Group, LLC.",

year = "2024",

doi = "10.1080/24701556.2021.2015385",

language = "English",

volume = "54",

pages = "165--176",

journal = "Inorganic and Nano-Metal Chemistry",

issn = "2470-1556",

publisher = "Taylor and Francis Ltd.",

number = "2",

}

TY - JOUR

T1 - New metal-based drugs

T2 - spectral, electrochemical, DNA-binding and anticancer activity properties

AU - Çeşme, Mustafa

AU - Muslu, Harun

AU - Tumer, Mehmet

AU - Güngör, Özge

AU - Altunbek, Mine

AU - Culha, Mustafa

AU - Golcu, Aysegul

PY - 2024

Y1 - 2024

N2 - The coordination compounds of antineoplastic chemotherapy drug of dacarbazine (DAC) with Zn(II) ([Zn(DAC)2] 3H2O; NGDCM1) and Cu(II) ([Cu(DAC)ClH2O]; NGDCM2) were synthesized and characterized using analytical and spectroscopic techniques. The electrochemical behaviors of the obtained new compounds and the starting active substance DAC were examined in detail. The interaction of all compounds with fish sperm double-stranded deoxyribonucleic acid (FSdsDNA) was investigated by measuring their binding constant (Kb) to FSdsDNA. Also, the competitive binding fluorescence spectroscopy studies with ethidium bromide (EtBr) were carried out. Furthermore, both compound’s anticancer activities were investigated on human lung cancer (A549) cells, and their effects were compared to other metals possessing antineoplastic drugs, including oxaliplatin and cisplatin.

AB - The coordination compounds of antineoplastic chemotherapy drug of dacarbazine (DAC) with Zn(II) ([Zn(DAC)2] 3H2O; NGDCM1) and Cu(II) ([Cu(DAC)ClH2O]; NGDCM2) were synthesized and characterized using analytical and spectroscopic techniques. The electrochemical behaviors of the obtained new compounds and the starting active substance DAC were examined in detail. The interaction of all compounds with fish sperm double-stranded deoxyribonucleic acid (FSdsDNA) was investigated by measuring their binding constant (Kb) to FSdsDNA. Also, the competitive binding fluorescence spectroscopy studies with ethidium bromide (EtBr) were carried out. Furthermore, both compound’s anticancer activities were investigated on human lung cancer (A549) cells, and their effects were compared to other metals possessing antineoplastic drugs, including oxaliplatin and cisplatin.

KW - DNA binding

KW - Metal-based drugs

KW - antineoplastic

KW - dacarbazine

UR - http://www.scopus.com/inward/record.url?scp=85121571356&partnerID=8YFLogxK

U2 - 10.1080/24701556.2021.2015385

DO - 10.1080/24701556.2021.2015385

M3 - Article

AN - SCOPUS:85121571356

SN - 2470-1556

VL - 54

SP - 165

EP - 176

JO - Inorganic and Nano-Metal Chemistry

JF - Inorganic and Nano-Metal Chemistry

IS - 2

ER -

New metal-based drugs: spectral, electrochemical, DNA-binding and anticancer activity properties

Özet

Bibliyografik not

Finansman

BM SKH

Belgeye Erişim

Diğer Dosyalar ve Linkler

Parmak izi

Alıntı Yap