TY - JOUR
T1 - Natural products of relevance in the management of attention deficit hyperactivity disorder
AU - Custódio, Luísa
AU - Vizetto-Duarte, Catarina
AU - Cebeci, Fatma
AU - Özçelik, Beraat
AU - Sharopov, Farukh
AU - Gürer, Eda Sönmez
AU - Kumar, Manoj
AU - Iriti, Marcello
AU - Sharifi-Rad, Javad
AU - Calina, Daniela
N1 - Publisher Copyright:
© 2022 The Authors. eFood published by John Wiley & Sons Australia, Ltd. on behalf of International Association of Dietetic Nutrition and Safety.
PY - 2023/2
Y1 - 2023/2
N2 - Attention deficit hyperactivity disorder (ADHD) is among the most common neurodevelopmental disorders characterized by motor hyperactivity, attention deficit, distraction, impulsive behavior, and relationship difficulties. It affects children, and thus over the years, there has been growing attention on the use of natural product formulations and their naturally-occurring bioactive for overcoming the problem of ADHD. Concerning this issue, this review aims to discuss the ADHD treatment potential of natural products/formulations in vitro, in vivo as well as in clinical trials. To gather the most relevant data regarding bioactive compounds with potential therapeutic effects in the management of ADHD, the following databases were searched: PubMed/MedLine, ScienceDirect, and Google Scholar for articles in English. Various medicinal plants and their isolated biomolecules have been evaluated in vitro, in vivo, and in clinical trials for their ability to treat ADHD. Most of the analyzed research results showed an improvement of ADHD signs and symptoms in in vivo models, but the molecular mechanisms of action of the bioactive compounds are unclear and incompletely elucidated. Further studies are needed to determine the bioactive compound responsible for health-promoting effects in ADHD. In addition, clinical studies should be performed over longer periods with more participants.
AB - Attention deficit hyperactivity disorder (ADHD) is among the most common neurodevelopmental disorders characterized by motor hyperactivity, attention deficit, distraction, impulsive behavior, and relationship difficulties. It affects children, and thus over the years, there has been growing attention on the use of natural product formulations and their naturally-occurring bioactive for overcoming the problem of ADHD. Concerning this issue, this review aims to discuss the ADHD treatment potential of natural products/formulations in vitro, in vivo as well as in clinical trials. To gather the most relevant data regarding bioactive compounds with potential therapeutic effects in the management of ADHD, the following databases were searched: PubMed/MedLine, ScienceDirect, and Google Scholar for articles in English. Various medicinal plants and their isolated biomolecules have been evaluated in vitro, in vivo, and in clinical trials for their ability to treat ADHD. Most of the analyzed research results showed an improvement of ADHD signs and symptoms in in vivo models, but the molecular mechanisms of action of the bioactive compounds are unclear and incompletely elucidated. Further studies are needed to determine the bioactive compound responsible for health-promoting effects in ADHD. In addition, clinical studies should be performed over longer periods with more participants.
KW - ADHD
KW - clinical studies
KW - natural products
KW - pharmacotherapeutic management
KW - preclinical studies
UR - http://www.scopus.com/inward/record.url?scp=85147213223&partnerID=8YFLogxK
U2 - 10.1002/efd2.57
DO - 10.1002/efd2.57
M3 - Review article
AN - SCOPUS:85147213223
SN - 2666-3066
VL - 4
JO - eFood
JF - eFood
IS - 1
M1 - e57
ER -