TY - GEN
T1 - Mesenchymal stem cell differentiation by nano-engineered Si columns
AU - Trabzon, Levent
AU - Ramazanoglu, Mustafa
AU - Kizil, Huseyin
AU - Guvendik, Sebahattin
PY - 2011
Y1 - 2011
N2 - We successfully engineered Si nano-columns with different cross-sectional geometries by e-beam evaporation with an angle between source and substrate. The Si nano-columns were grown as pillars with square, triangle and linear cross sections in in-plane. Mesenchymal stem cells (MSCs) isolated from the bone marrow stroma of young adult rats were cultured on these different Si nanosurfaces. We found that the behaviour of MSCs highly depended on the geometry of nano-topography so that mesenchymal stem cells were differentiated and induced CaP precipitation on square-cross-sectional Si nano-columns without growth factor in the culture medium.
AB - We successfully engineered Si nano-columns with different cross-sectional geometries by e-beam evaporation with an angle between source and substrate. The Si nano-columns were grown as pillars with square, triangle and linear cross sections in in-plane. Mesenchymal stem cells (MSCs) isolated from the bone marrow stroma of young adult rats were cultured on these different Si nanosurfaces. We found that the behaviour of MSCs highly depended on the geometry of nano-topography so that mesenchymal stem cells were differentiated and induced CaP precipitation on square-cross-sectional Si nano-columns without growth factor in the culture medium.
KW - Biomaterials
KW - Nano-Columns
KW - Stem Cells
UR - http://www.scopus.com/inward/record.url?scp=79957881227&partnerID=8YFLogxK
U2 - 10.1109/MECBME.2011.5752061
DO - 10.1109/MECBME.2011.5752061
M3 - Conference contribution
AN - SCOPUS:79957881227
SN - 9781424470006
T3 - 2011 1st Middle East Conference on Biomedical Engineering, MECBME 2011
SP - 45
EP - 48
BT - 2011 1st Middle East Conference on Biomedical Engineering, MECBME 2011
T2 - 2011 1st Middle East Conference on Biomedical Engineering, MECBME 2011
Y2 - 21 February 2011 through 24 February 2011
ER -