Master regulators, Regulatory networks, And pathways of glioblastoma subtypes

Serdar Bozdag*, Aiguo Li, Mehmet Baysan, Howard A. Fine

*Bu çalışma için yazışmadan sorumlu yazar

Araştırma sonucu: ???type-name???Makalebilirkişi

11 Atıf (Scopus)

Özet

Glioblastoma multiforme (GBM) is the most common malignant brain tumor. GBM samples are classified into subtypes based on their tran- scriptomic and epigenetic profiles. Despite numerous studies to better characterize GBM biology, a comprehensive study to identify GBM subtype-specific master regulators, gene regulatory networks, and pathways is missing. Here, we used FastMEDUSA to compute master regulators and gene regulatory networks for each GBM subtype. We also ran Gene Set Enrichment Analysis and Ingenuity Pathway Analysis on GBM expression dataset from The Cancer Genome Atlas Project to compute GBM- and GBM subtype-specific pathways. Our analysis was able to recover some of the known master regulators and pathways in GBM as well as some putative novel regulators and pathways, which will aide in our understanding of the unique biology of GBM subtypes.

Orijinal dilİngilizce
Sayfa (başlangıç-bitiş)33-44
Sayfa sayısı12
DergiCancer Informatics
Hacim13
DOI'lar
Yayın durumuYayınlandı - 15 Eki 2014
Harici olarak yayınlandıEvet

Bibliyografik not

Publisher Copyright:
© the authors, publisher and licensee Libertas Academica Limited.

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