Investigation of the biological properties of water soluble quinoline substituted phthalocyanines

Didem Evren; Ibrahim Özçeşmeci; B. Şebnem Sesalan; Ayfer Kalkan Burat

doi:10.1016/j.synthmet.2013.02.015

Investigation of the biological properties of water soluble quinoline substituted phthalocyanines

Didem Evren
, Ibrahim Özçeşmeci
, B. Şebnem Sesalan^*
, Ayfer Kalkan Burat

^*Bu çalışma için yazışmadan sorumlu yazar

Kimya Bölümü

Istanbul Technical University

Araştırma sonucu: Dergiye katkı › Makale › bilirkişi

22 Atıf (Scopus)

Özet

The interaction between water soluble quinoline substituted phthalocyanines (Pcs) 1Q and 2Q and BSA (bovine serum albumin) was investigated. The binding modes of 1Q and 2Q to BSA was investigated by UV-vis and fluorescence titration experiments. The quenching effect of Pcs 1Q and 2Q on the fluorescence of Acridine Orange (AO)-BSA complex was determined. The results indicated that these water soluble phthalocyanines (Pcs) can bind to BSA and can be transported in circulatory system. Water soluble nature of both Pcs enhances cellular uptake and these dyes can be used in photodynamic theraphy (PDT).

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	31-35
Sayfa sayısı	5
Dergi	Synthetic Metals
Hacim	168
Basın numarası	1
DOI'lar	https://doi.org/10.1016/j.synthmet.2013.02.015
Yayın durumu	Yayınlandı - 2013

Finansman

This work was supported by TUBITAK (Project no: 110T800).

Finansörler	Finansör numarası
TUBITAK	110T800

Belgeye Erişim

10.1016/j.synthmet.2013.02.015

Diğer Dosyalar ve Linkler

Link to publication in Scopus

Alıntı Yap

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title = "Investigation of the biological properties of water soluble quinoline substituted phthalocyanines",

abstract = "The interaction between water soluble quinoline substituted phthalocyanines (Pcs) 1Q and 2Q and BSA (bovine serum albumin) was investigated. The binding modes of 1Q and 2Q to BSA was investigated by UV-vis and fluorescence titration experiments. The quenching effect of Pcs 1Q and 2Q on the fluorescence of Acridine Orange (AO)-BSA complex was determined. The results indicated that these water soluble phthalocyanines (Pcs) can bind to BSA and can be transported in circulatory system. Water soluble nature of both Pcs enhances cellular uptake and these dyes can be used in photodynamic theraphy (PDT).",

keywords = "Acridineorange, BSA, Fluorescence, Phthalocyanine",

author = "Didem Evren and Ibrahim {\"O}z{\c c}e{\c s}meci and Sesalan, \{B. {\c S}ebnem\} and Burat, \{Ayfer Kalkan\}",

year = "2013",

doi = "10.1016/j.synthmet.2013.02.015",

language = "English",

volume = "168",

pages = "31--35",

journal = "Synthetic Metals",

issn = "0379-6779",

publisher = "Elsevier B.V.",

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}

TY - JOUR

T1 - Investigation of the biological properties of water soluble quinoline substituted phthalocyanines

AU - Evren, Didem

AU - Özçeşmeci, Ibrahim

AU - Sesalan, B. Şebnem

AU - Burat, Ayfer Kalkan

PY - 2013

Y1 - 2013

N2 - The interaction between water soluble quinoline substituted phthalocyanines (Pcs) 1Q and 2Q and BSA (bovine serum albumin) was investigated. The binding modes of 1Q and 2Q to BSA was investigated by UV-vis and fluorescence titration experiments. The quenching effect of Pcs 1Q and 2Q on the fluorescence of Acridine Orange (AO)-BSA complex was determined. The results indicated that these water soluble phthalocyanines (Pcs) can bind to BSA and can be transported in circulatory system. Water soluble nature of both Pcs enhances cellular uptake and these dyes can be used in photodynamic theraphy (PDT).

AB - The interaction between water soluble quinoline substituted phthalocyanines (Pcs) 1Q and 2Q and BSA (bovine serum albumin) was investigated. The binding modes of 1Q and 2Q to BSA was investigated by UV-vis and fluorescence titration experiments. The quenching effect of Pcs 1Q and 2Q on the fluorescence of Acridine Orange (AO)-BSA complex was determined. The results indicated that these water soluble phthalocyanines (Pcs) can bind to BSA and can be transported in circulatory system. Water soluble nature of both Pcs enhances cellular uptake and these dyes can be used in photodynamic theraphy (PDT).

KW - Acridineorange

KW - BSA

KW - Fluorescence

KW - Phthalocyanine

UR - https://www.scopus.com/pages/publications/84875206967

U2 - 10.1016/j.synthmet.2013.02.015

DO - 10.1016/j.synthmet.2013.02.015

M3 - Article

AN - SCOPUS:84875206967

SN - 0379-6779

VL - 168

SP - 31

EP - 35

JO - Synthetic Metals

JF - Synthetic Metals

IS - 1

ER -

Investigation of the biological properties of water soluble quinoline substituted phthalocyanines

Özet

Finansman

Belgeye Erişim

Diğer Dosyalar ve Linkler

Parmak izi

Alıntı Yap