Investigating the effects of supercritical antisolvent process and food models on antioxidant capacity, bioaccessibility and transepithelial transport of quercetin and rutin

Gulay Ozkan, Paola Franco, Iolanda De Marco, Esra Capanoglu*, Tuba Esatbeyoglu*

*Bu çalışma için yazışmadan sorumlu yazar

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6 Atıf (Scopus)

Özet

In the present study, the effects of the Supercritical Anti-Solvent (SAS) process and food models on the antioxidant capacity, bioaccessibility and transport dynamics of flavonol-loaded polyvinylpyrrolidone (PVP) based microparticles were investigated using a combined in vitro gastrointestinal digestion/Caco-2 cell culture model. SAS-processed and unprocessed flavonols were supplied in two different food models: 10% ethanol for an aqueous hydrophilic food simulant and 3% acetic acid for an acidic food simulant. The SAS processing of quercetin and rutin resulted in a much higher recovery of these bioactives as well as greater retention of antioxidant capacity after gastrointestinal digestion in both hydrophilic and acidic food models. The present study also demonstrates that SAS coprecipitation has a positive effect on the stability and transport of bioactives across the epithelial cell layer. It can be deduced from the results that the SAS process can be a useful method in pharmaceutical and nutraceutical applications with high stability, bioaccessibility, bioavailability and thus enhanced nutritional value.

Orijinal dilİngilizce
Sayfa (başlangıç-bitiş)4469-4477
Sayfa sayısı9
DergiFood and Function
Hacim13
Basın numarası8
DOI'lar
Yayın durumuYayınlandı - 14 Mar 2022

Bibliyografik not

Publisher Copyright:
© 2022 The Royal Society of Chemistry.

Finansman

This work was supported by the Istanbul Technical University, Scientific Research Projects (BAP) Unit [project number MDK-2018-41359].

FinansörlerFinansör numarası
Istanbul Teknik ÜniversitesiMDK-2018-41359

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