In vivo dielectric properties of healthy and benign rat mammary tissues from 500 mhz to 18 ghz

Tuba Yilmaz; Fatma Ates Alkan

doi:10.3390/s20082214

In vivo dielectric properties of healthy and benign rat mammary tissues from 500 mhz to 18 ghz

Tuba Yilmaz^*, Fatma Ates Alkan

^*Bu çalışma için yazışmadan sorumlu yazar

Elektronik ve Hab.Müh.Bölümü

Beykent University

Araştırma sonucu: ???type-name??? › Makale › bilirkişi

17 Atıf (Scopus)

Özet

This work investigates the in vivo dielectric properties of healthy and benign rat mammary tissues in an attempt to expand the dielectric property knowledge of animal models. The outcomes of this study can enable testing of microwave medical technologies on animal models and interpretation of tissue alteration-dependent in vivo dielectric properties of mammary tissues. Towards this end, in vivo dielectric properties of healthy rat mammary tissues and chemically induced benign rat mammary tumors including low-grade adenosis, sclerosing adenosis, and adenosis were collected with open-ended coaxial probes from 500 MHz to 18 GHz. The in vivo measurements revealed that the dielectric properties of benign rat mammary tumors are higher than the healthy rat mammary tissues by 9.3% to 35.5% and 19.6% to 48.7% for relative permittivity and conductivity, respectively. Furthermore, to our surprise, we found that the grade of the benign tissue affects the dielectric properties for this study. Finally, a comparison with ex vivo healthy human mammary tissue dielectric properties revealed that the healthy rat mammary tissues best replicate the dielectric properties of healthy medium density human samples.

Orijinal dil	İngilizce
Makale numarası	2214
Dergi	Sensors
Hacim	20
Basın numarası	8
DOI'lar	https://doi.org/10.3390/s20082214
Yayın durumu	Yayınlandı - 2 Nis 2020

Bibliyografik not

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Finansman

Funding: This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 750346 and the Istanbul Technical University under grant agreement 41554. This project has received funding from the European Union?s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 750346 and the Istanbul Technical University under grant agreement 41554. The authors would like to thank the VIVARIUM team for their input to the experimental procedure through fruitful discussions and their help on handling of the animals. The authors would also like to thank the MIDxPRO team for their assistance during the experiments.

Finansörler	Finansör numarası
VIVARIUM
Horizon 2020 Framework Programme
H2020 Marie Skłodowska-Curie Actions	750346
Istanbul Teknik Üniversitesi	41554

BM SKH

Bu sonuç, aşağıdaki Sürdürülebilir Kalkınma Hedefine/Hedeflerine katkıda bulunur

Belgeye Erişim

10.3390/s20082214

Diğer Dosyalar ve Linkler

Link to publication in Scopus

Alıntı Yap

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title = "In vivo dielectric properties of healthy and benign rat mammary tissues from 500 mhz to 18 ghz",

abstract = "This work investigates the in vivo dielectric properties of healthy and benign rat mammary tissues in an attempt to expand the dielectric property knowledge of animal models. The outcomes of this study can enable testing of microwave medical technologies on animal models and interpretation of tissue alteration-dependent in vivo dielectric properties of mammary tissues. Towards this end, in vivo dielectric properties of healthy rat mammary tissues and chemically induced benign rat mammary tumors including low-grade adenosis, sclerosing adenosis, and adenosis were collected with open-ended coaxial probes from 500 MHz to 18 GHz. The in vivo measurements revealed that the dielectric properties of benign rat mammary tumors are higher than the healthy rat mammary tissues by 9.3% to 35.5% and 19.6% to 48.7% for relative permittivity and conductivity, respectively. Furthermore, to our surprise, we found that the grade of the benign tissue affects the dielectric properties for this study. Finally, a comparison with ex vivo healthy human mammary tissue dielectric properties revealed that the healthy rat mammary tissues best replicate the dielectric properties of healthy medium density human samples.",

keywords = "DMBA-induced benign tumors, In vivo dielectric properties, Rat mammary tissues",

author = "Tuba Yilmaz and Alkan, {Fatma Ates}",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = apr,

day = "2",

doi = "10.3390/s20082214",

language = "English",

volume = "20",

journal = "Sensors",

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publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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TY - JOUR

T1 - In vivo dielectric properties of healthy and benign rat mammary tissues from 500 mhz to 18 ghz

AU - Yilmaz, Tuba

AU - Alkan, Fatma Ates

PY - 2020/4/2

Y1 - 2020/4/2

N2 - This work investigates the in vivo dielectric properties of healthy and benign rat mammary tissues in an attempt to expand the dielectric property knowledge of animal models. The outcomes of this study can enable testing of microwave medical technologies on animal models and interpretation of tissue alteration-dependent in vivo dielectric properties of mammary tissues. Towards this end, in vivo dielectric properties of healthy rat mammary tissues and chemically induced benign rat mammary tumors including low-grade adenosis, sclerosing adenosis, and adenosis were collected with open-ended coaxial probes from 500 MHz to 18 GHz. The in vivo measurements revealed that the dielectric properties of benign rat mammary tumors are higher than the healthy rat mammary tissues by 9.3% to 35.5% and 19.6% to 48.7% for relative permittivity and conductivity, respectively. Furthermore, to our surprise, we found that the grade of the benign tissue affects the dielectric properties for this study. Finally, a comparison with ex vivo healthy human mammary tissue dielectric properties revealed that the healthy rat mammary tissues best replicate the dielectric properties of healthy medium density human samples.

AB - This work investigates the in vivo dielectric properties of healthy and benign rat mammary tissues in an attempt to expand the dielectric property knowledge of animal models. The outcomes of this study can enable testing of microwave medical technologies on animal models and interpretation of tissue alteration-dependent in vivo dielectric properties of mammary tissues. Towards this end, in vivo dielectric properties of healthy rat mammary tissues and chemically induced benign rat mammary tumors including low-grade adenosis, sclerosing adenosis, and adenosis were collected with open-ended coaxial probes from 500 MHz to 18 GHz. The in vivo measurements revealed that the dielectric properties of benign rat mammary tumors are higher than the healthy rat mammary tissues by 9.3% to 35.5% and 19.6% to 48.7% for relative permittivity and conductivity, respectively. Furthermore, to our surprise, we found that the grade of the benign tissue affects the dielectric properties for this study. Finally, a comparison with ex vivo healthy human mammary tissue dielectric properties revealed that the healthy rat mammary tissues best replicate the dielectric properties of healthy medium density human samples.

KW - DMBA-induced benign tumors

KW - In vivo dielectric properties

KW - Rat mammary tissues

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U2 - 10.3390/s20082214

DO - 10.3390/s20082214

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C2 - 32295215

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SN - 1424-8220

VL - 20

JO - Sensors

JF - Sensors

IS - 8

M1 - 2214

ER -

In vivo dielectric properties of healthy and benign rat mammary tissues from 500 mhz to 18 ghz

Özet

Bibliyografik not

Finansman

BM SKH

Belgeye Erişim

Diğer Dosyalar ve Linkler

Parmak izi

Alıntı Yap