Improved mechanical properties of antimicrobial poly(N-[3-(dimethylaminopropyl)] methacrylamide) hydrogels prepared by free radical polymerization in the presence of cetyltrimethylammonium bromide as a lyotropic liquid crystal template

Cansu Kozbekci Sabah, Bestenur Yalçın, Ceyda Şimşek, Yeşim H. Gürsel, Candan Erbil*

*Bu çalışma için yazışmadan sorumlu yazar

Araştırma sonucu: Dergiye katkıMakalebilirkişi

3 Atıf (Scopus)

Özet

The poor mechanical strength of the poly(N-[3-(dimethylamino)propyl] methacrylamide) (PDMAPMAAm) hydrogel limits its application as a drug delivery system and antimicrobial agent. In this study, both its morphology and antibacterial effectiveness were controlled through free radical solution polymerization in the presence of cetyltrimethylammonium bromide (CTAB; cationic nonreactive surfactant), forming lyotropic liquid crystal (LLC) mesophases. All the templated reactions proceeded in four different CTAB concentrations with three different concentrations of DMAPMAAm (2.0, 3.0 and 4.0 mol L−1), which were carried out in distilled-deionized water (DDW) using potassium persulfate (KPS) and N,N′-methylenebisacrylamide (BIS) as the initiator and crosslinker, respectively. The pH-dependent phase transition temperature (34 °C at pH 14), compression moduli, antibacterial and diffusion properties, and the effect of the LLC mesophases of CTAB on the hydrogel properties were investigated by mechanical measurements, image analysis, inhibition zone tests, X-ray diffractograms and polarized optical microscopy (POM). It was found that the compression moduli of the templated (T)-PDMAPMAAm hydrogels increased by nearly ten times (from ∼3.0 to 30.0 kPa) compared to that of the isotropic (I) ones. The POM and XRD results before the removal of CTAB exhibited the formation of lamellar and hexagonal mesophases. Further, the inhibition zones showed the ability of the I-PDMAPMAAm hydrogels to reduce the activity of E. coli even in the absence of CTAB, gentamicin (GS) and ciprofloxacin (CF). This was because the quaternary ammonium (QA) groups on the DMAPMAAm units could interact with the bacterial membrane.

Orijinal dilİngilizce
Sayfa (başlangıç-bitiş)4156-4166
Sayfa sayısı11
DergiSoft Matter
Hacim18
Basın numarası21
DOI'lar
Yayın durumuYayınlandı - 5 May 2022

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Publisher Copyright:
© 2022 The Royal Society of Chemistry.

Finansman

We would like to inform that this work was supported by Istanbul Technical University Scientific Research Project Council (38858) and the Scientific and Technological Research Council of Turkey under Project number 115Z876.

FinansörlerFinansör numarası
Istanbul Technical University Scientific Research Project Council38858
Türkiye Bilimsel ve Teknolojik Araştırma Kurumu115Z876

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