G-cimp status prediction of glioblastoma samples using mRNA expression data.

Mehmet Baysan*, Serdar Bozdag, Margaret C. Cam, Svetlana Kotliarova, Susie Ahn, Jennifer Walling, Jonathan K. Killian, Holly Stevenson, Paul Meltzer, Howard A. Fine

*Bu çalışma için yazışmadan sorumlu yazar

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Özet

Glioblastoma Multiforme (GBM) is a tumor with high mortality and no known cure. The dramatic molecular and clinical heterogeneity seen in this tumor has led to attempts to define genetically similar subgroups of GBM with the hope of developing tumor specific therapies targeted to the unique biology within each of these subgroups. Recently, a subset of relatively favorable prognosis GBMs has been identified. These glioma CpG island methylator phenotype, or G-CIMP tumors, have distinct genomic copy number aberrations, DNA methylation patterns, and (mRNA) expression profiles compared to other GBMs. While the standard method for identifying G-CIMP tumors is based on genome-wide DNA methylation data, such data is often not available compared to the more widely available gene expression data. In this study, we have developed and evaluated a method to predict the G-CIMP status of GBM samples based solely on gene expression data.

Orijinal dilİngilizce
DergiPLoS ONE
Hacim7
Basın numarası11
DOI'lar
Yayın durumuYayınlandı - 2012
Harici olarak yayınlandıEvet

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