Enhancing magnetic resonance imaging tumor detection with fluorescence intensity and lifetime imaging

Ahmet Erten, David Hall, Carl Hoh, Hop S. Tran Cao, Sharmeela Kaushal, Sadik Esener, Robert M. Hoffman, Michael Bouvet, James Chen, Santosh Kesari, Milan Makale*

*Bu çalışma için yazışmadan sorumlu yazar

Araştırma sonucu: ???type-name???Makalebilirkişi

6 Atıf (Scopus)

Özet

Early detection is important for many solid cancers but the images provided by ultrasound, magnetic resonance imaging (MRI), and computed tomography applied alone or together, are often not sufficient for decisive early screeningdiagnosis. We demonstrate that MRI augmented with fluorescence intensity (FI) substantially improves detection. Early stage murine pancreatic tumors that could not be identified by blinded, skilled observers using MRI alone, were easily identified with MRI along with FI images acquired with photomultiplier tube detection and offset laser scanning. Moreover, we show that fluorescence lifetime (FLT) imaging enables positive identification of the labeling fluorophore and discriminates it from surrounding tissue autofluorescence. Our data suggest combined-modality imaging with MRI, FI, and FLT can be used to screen and diagnose early tumors.

Orijinal dilİngilizce
Makale numarası066012
DergiJournal of Biomedical Optics
Hacim15
Basın numarası6
DOI'lar
Yayın durumuYayınlandı - Kas 2010
Harici olarak yayınlandıEvet

Finansman

The authors wish to acknowledge the excellent editorial assistance of Ms. Charlene M. Cooper, and the expert imaging assistance provided by Mr. Salman Farshchi-Haydari. This work was in part funded by the National Cancer Institute Grant No. CA109949 and the American Cancer Society Grant No. RSG-05-037-01-CCE (to M.B.), T32 training Grant No. CA121938 (to H.S.T.C.), National Cancer Institute Grant No. CA132971 (to M.B. and AntiCancer Inc.), National Institutes of Health (NIH) Grant No. S10 RR22599-01A1 (to D.J.H) and NIH Grant No. P50 CA128346-01A1.

FinansörlerFinansör numarası
AntiCancer Inc.
National Institutes of HealthS10 RR22599-01A1
American Cancer SocietyCA121938, RSG-05-037-01-CCE
National Cancer InstituteCA109949, R01CA132971

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