Electrosprayed chitin nanofibril/electrospun polyhydroxyalkanoate fiber mesh as functional nonwoven for skin application

Bahareh Azimi, Lily Thomas, Alessandra Fusco, Ozlem Ipek Kalaoglu-Altan, Pooja Basnett, Patrizia Cinelli, Karen de Clerck, Ipsita Roy, Giovanna Donnarumma, Maria Beatrice Coltelli, Serena Danti*, Andrea Lazzeri

*Bu çalışma için yazışmadan sorumlu yazar

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49 Atıf (Scopus)

Özet

Polyhydroxyalkanoates (PHAs) are a family of bio-based polyesters that have found different biomedical applications. Chitin and lignin, byproducts of fishery and plant biomass, show antimicrobial and anti-inflammatory activity on the nanoscale. Due to their polarities, chitin nanofibril (CN) and nanolignin (NL) can be assembled into micro-complexes, which can be loaded with bioactive factors, such as the glycyrrhetinic acid (GA) and CN-NL/GA (CLA) complexes, and can be used to decorate polymer surfaces. This study aims to develop completely bio-based and bioactive meshes intended for wound healing. Poly(3-hydroxybutyrate)/ Poly(3-hydroxyoctanoate-co-3-hydroxydecanoate), P(3HB)/P(3HO-co-3HD) was used to produce films and fiber meshes, to be surface-modified via electrospraying of CN or CLA to reach a uniform distribution. P(3HB)/P(3HO-co-3HD) fibers with desirable size and morphology were successfully prepared and functionalized with CN and CLA using electrospinning and tested in vitro with human keratinocytes. The presence of CN and CLA improved the indirect antimicrobial and anti-inflammatory activity of the electrospun fiber meshes by downregulating the expression of the most important pro-inflammatory cytokines and upregulating human defensin 2 expression. This natural and eco-sustainable mesh is promising in wound healing applications.

Orijinal dilİngilizce
Makale numarası62
DergiJournal of Functional Biomaterials
Hacim11
Basın numarası3
DOI'lar
Yayın durumuYayınlandı - Eyl 2020
Harici olarak yayınlandıEvet

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© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

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