Electrochemical investigation and DNA-binding studies of valacyclovir-copper(II) complex

Derya Tarinc; Aysegul Golcu; Mehmet Tumer; Taner Karaoglu; Mehmet Ozsoz

doi:10.1080/15533174.2012.680136

Electrochemical investigation and DNA-binding studies of valacyclovir-copper(II) complex

Derya Tarinc
, Aysegul Golcu^*
, Mehmet Tumer
, Taner Karaoglu
, Mehmet Ozsoz

^*Bu çalışma için yazışmadan sorumlu yazar

Araştırma sonucu: Dergiye katkı › Makale › bilirkişi

2 Atıf (Scopus)

Özet

The synthesis and the electrochemical characterization of copper(II) complex containing one molecule of antiviral drug, valacyclovir (VAL), is reported. In addition to characterization, the electrochemical properties of the copper(II) complex of VAL ([Cu(VAL)Cl₂]) were investigated by cyclic voltammetry (CV) using glassy carbon electrode. The redox properties of the metal complex was reversible and exhibited diffusion controlled process depending on pH. The dependence of intensities of currents and potentials on pH, concentration, scan rate, and nature of the buffer was investigated. The oxidation/reduction mechanism was proposed and discussed. Also, the interaction of copper complex of VAL- with calf thymus double-stranded DNA was studied spectrophotometrically (UV-vis) and electrochemically by using CV at glassy carbon working electrode. Additionally, the cytotoxicity activity of complex has been investigated against the bovine herpes virus type I.

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	140-148
Sayfa sayısı	9
Dergi	Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry
Hacim	43
Basın numarası	2
DOI'lar	https://doi.org/10.1080/15533174.2012.680136
Yayın durumu	Yayınlandı - 1 Şub 2013
Harici olarak yayınlandı	Evet

Finansman

Received 25 August 2011; accepted 27 December 2011. The authors wish to thank TUBITAK (Project No: 109T020) and KSU (Project No: 2009/3–10) for the financial support. Address correspondence to Aysegul Golcu, Department of Chemistry, Faculty of Science and Letters, University of Kahramanmaras Sutcu Imam, Campuse of Avsar 46100, Kahramanmaras, Turkey. E-mail: [email protected]

Finansörler	Finansör numarası
TUBITAK	109T020
Kennesaw State University	2009/3–10

Belgeye Erişim

10.1080/15533174.2012.680136

Diğer Dosyalar ve Linkler

Link to publication in Scopus

Alıntı Yap

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title = "Electrochemical investigation and DNA-binding studies of valacyclovir-copper(II) complex",

abstract = "The synthesis and the electrochemical characterization of copper(II) complex containing one molecule of antiviral drug, valacyclovir (VAL), is reported. In addition to characterization, the electrochemical properties of the copper(II) complex of VAL ([Cu(VAL)Cl2]) were investigated by cyclic voltammetry (CV) using glassy carbon electrode. The redox properties of the metal complex was reversible and exhibited diffusion controlled process depending on pH. The dependence of intensities of currents and potentials on pH, concentration, scan rate, and nature of the buffer was investigated. The oxidation/reduction mechanism was proposed and discussed. Also, the interaction of copper complex of VAL- with calf thymus double-stranded DNA was studied spectrophotometrically (UV-vis) and electrochemically by using CV at glassy carbon working electrode. Additionally, the cytotoxicity activity of complex has been investigated against the bovine herpes virus type I.",

keywords = "DNA binding, drug-metal complex, valacyclovir, voltammetry",

author = "Derya Tarinc and Aysegul Golcu and Mehmet Tumer and Taner Karaoglu and Mehmet Ozsoz",

year = "2013",

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doi = "10.1080/15533174.2012.680136",

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T1 - Electrochemical investigation and DNA-binding studies of valacyclovir-copper(II) complex

AU - Tarinc, Derya

AU - Golcu, Aysegul

AU - Tumer, Mehmet

AU - Karaoglu, Taner

AU - Ozsoz, Mehmet

PY - 2013/2/1

Y1 - 2013/2/1

N2 - The synthesis and the electrochemical characterization of copper(II) complex containing one molecule of antiviral drug, valacyclovir (VAL), is reported. In addition to characterization, the electrochemical properties of the copper(II) complex of VAL ([Cu(VAL)Cl2]) were investigated by cyclic voltammetry (CV) using glassy carbon electrode. The redox properties of the metal complex was reversible and exhibited diffusion controlled process depending on pH. The dependence of intensities of currents and potentials on pH, concentration, scan rate, and nature of the buffer was investigated. The oxidation/reduction mechanism was proposed and discussed. Also, the interaction of copper complex of VAL- with calf thymus double-stranded DNA was studied spectrophotometrically (UV-vis) and electrochemically by using CV at glassy carbon working electrode. Additionally, the cytotoxicity activity of complex has been investigated against the bovine herpes virus type I.

AB - The synthesis and the electrochemical characterization of copper(II) complex containing one molecule of antiviral drug, valacyclovir (VAL), is reported. In addition to characterization, the electrochemical properties of the copper(II) complex of VAL ([Cu(VAL)Cl2]) were investigated by cyclic voltammetry (CV) using glassy carbon electrode. The redox properties of the metal complex was reversible and exhibited diffusion controlled process depending on pH. The dependence of intensities of currents and potentials on pH, concentration, scan rate, and nature of the buffer was investigated. The oxidation/reduction mechanism was proposed and discussed. Also, the interaction of copper complex of VAL- with calf thymus double-stranded DNA was studied spectrophotometrically (UV-vis) and electrochemically by using CV at glassy carbon working electrode. Additionally, the cytotoxicity activity of complex has been investigated against the bovine herpes virus type I.

KW - DNA binding

KW - drug-metal complex

KW - valacyclovir

KW - voltammetry

UR - https://www.scopus.com/pages/publications/84872020356

U2 - 10.1080/15533174.2012.680136

DO - 10.1080/15533174.2012.680136

M3 - Article

AN - SCOPUS:84872020356

SN - 1553-3174

VL - 43

SP - 140

EP - 148

JO - Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry

JF - Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry

IS - 2

ER -

Electrochemical investigation and DNA-binding studies of valacyclovir-copper(II) complex

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