Dual laser activatable brominated hemicyanine as a highly efficient and photostable multimodal phototherapy agent

Hande Gunduz; Kubra Bilici; Sultan Cetin; Abdullah Muti; Alphan Sennaroglu; Havva Yagci Acar; Safacan Kolemen

doi:10.1016/j.jphotobiol.2021.112171

Dual laser activatable brominated hemicyanine as a highly efficient and photostable multimodal phototherapy agent

Hande Gunduz
, Kubra Bilici
, Sultan Cetin
, Abdullah Muti
, Alphan Sennaroglu^*
, Havva Yagci Acar
, Safacan Kolemen

^*Bu çalışma için yazışmadan sorumlu yazar

Koc University

Araştırma sonucu: Dergiye katkı › Makale › bilirkişi

11 Atıf (Scopus)

Özet

Dual phototherapy agents have attracted great interest in recent years as they offer enhanced cytotoxicity on cancer cells due to the synergistic effect of photodynamic and photothermal therapies (PDT/PTT). In this study, we demonstrate a brominated hemicyanine (HC-1), which is previously shown as mitochondria targeting PDT agent, can also serve as an effective photosensitizer for PTT for the first time under a single (640 nm or 808 nm) and dual laser (640 nm + 808 nm) irradiation. Generation of reactive oxygen species and photothermal conversion as a function of irradiation wavelength and power were studied. Both single wavelength irradiations caused significant phototoxicity in colon and cervical cancer cells after 5 min of irradiation. However, co-irradiation provided near-complete elimination of cancer cells due to synergistic action. This work introduces an easily accessible small molecule-based synergistic phototherapy agent, which holds a great promise towards the realization of local, rapid and highly efficient treatment modalities against cancer.

Orijinal dil	İngilizce
Makale numarası	112171
Dergi	Journal of Photochemistry and Photobiology B: Biology
Hacim	217
DOI'lar	https://doi.org/10.1016/j.jphotobiol.2021.112171
Yayın durumu	Yayınlandı - Nis 2021
Harici olarak yayınlandı	Evet

Bibliyografik not

Publisher Copyright:
© 2021 Elsevier B.V.

Finansman

The authors would like to thank Merve Erkısa, Berkay Civan, and Öznur Baykut for their help on flow cytometry measurements, to Işınsu Baylam for fluorescence quantum yield and 1 O 2 phosphorescence measurements and to Minahil Khan for laser experiments. SK thanks Koç University for financial support. Scheme 1 and TOC were created with BioRender.com .

Finansörler
Koç Üniversitesi

BM SKH

Bu sonuç, aşağıdaki Sürdürülebilir Kalkınma Hedefine/Hedeflerine katkıda bulunur

SKH 3 Sağlık ve Kaliteli Yaşam

Belgeye Erişim

10.1016/j.jphotobiol.2021.112171

Diğer Dosyalar ve Linkler

Link to publication in Scopus

Alıntı Yap

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title = "Dual laser activatable brominated hemicyanine as a highly efficient and photostable multimodal phototherapy agent",

abstract = "Dual phototherapy agents have attracted great interest in recent years as they offer enhanced cytotoxicity on cancer cells due to the synergistic effect of photodynamic and photothermal therapies (PDT/PTT). In this study, we demonstrate a brominated hemicyanine (HC-1), which is previously shown as mitochondria targeting PDT agent, can also serve as an effective photosensitizer for PTT for the first time under a single (640 nm or 808 nm) and dual laser (640 nm + 808 nm) irradiation. Generation of reactive oxygen species and photothermal conversion as a function of irradiation wavelength and power were studied. Both single wavelength irradiations caused significant phototoxicity in colon and cervical cancer cells after 5 min of irradiation. However, co-irradiation provided near-complete elimination of cancer cells due to synergistic action. This work introduces an easily accessible small molecule-based synergistic phototherapy agent, which holds a great promise towards the realization of local, rapid and highly efficient treatment modalities against cancer.",

keywords = "Cancer, Dual laser irradiation, Hemicyanine, Multimodal phototherapy, Small-molecule photosensitizers",

author = "Hande Gunduz and Kubra Bilici and Sultan Cetin and Abdullah Muti and Alphan Sennaroglu and \{Yagci Acar\}, Havva and Safacan Kolemen",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2021",

month = apr,

doi = "10.1016/j.jphotobiol.2021.112171",

language = "English",

volume = "217",

journal = "Journal of Photochemistry and Photobiology B: Biology",

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publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Dual laser activatable brominated hemicyanine as a highly efficient and photostable multimodal phototherapy agent

AU - Gunduz, Hande

AU - Bilici, Kubra

AU - Cetin, Sultan

AU - Muti, Abdullah

AU - Sennaroglu, Alphan

AU - Yagci Acar, Havva

AU - Kolemen, Safacan

PY - 2021/4

Y1 - 2021/4

N2 - Dual phototherapy agents have attracted great interest in recent years as they offer enhanced cytotoxicity on cancer cells due to the synergistic effect of photodynamic and photothermal therapies (PDT/PTT). In this study, we demonstrate a brominated hemicyanine (HC-1), which is previously shown as mitochondria targeting PDT agent, can also serve as an effective photosensitizer for PTT for the first time under a single (640 nm or 808 nm) and dual laser (640 nm + 808 nm) irradiation. Generation of reactive oxygen species and photothermal conversion as a function of irradiation wavelength and power were studied. Both single wavelength irradiations caused significant phototoxicity in colon and cervical cancer cells after 5 min of irradiation. However, co-irradiation provided near-complete elimination of cancer cells due to synergistic action. This work introduces an easily accessible small molecule-based synergistic phototherapy agent, which holds a great promise towards the realization of local, rapid and highly efficient treatment modalities against cancer.

AB - Dual phototherapy agents have attracted great interest in recent years as they offer enhanced cytotoxicity on cancer cells due to the synergistic effect of photodynamic and photothermal therapies (PDT/PTT). In this study, we demonstrate a brominated hemicyanine (HC-1), which is previously shown as mitochondria targeting PDT agent, can also serve as an effective photosensitizer for PTT for the first time under a single (640 nm or 808 nm) and dual laser (640 nm + 808 nm) irradiation. Generation of reactive oxygen species and photothermal conversion as a function of irradiation wavelength and power were studied. Both single wavelength irradiations caused significant phototoxicity in colon and cervical cancer cells after 5 min of irradiation. However, co-irradiation provided near-complete elimination of cancer cells due to synergistic action. This work introduces an easily accessible small molecule-based synergistic phototherapy agent, which holds a great promise towards the realization of local, rapid and highly efficient treatment modalities against cancer.

KW - Cancer

KW - Dual laser irradiation

KW - Hemicyanine

KW - Multimodal phototherapy

KW - Small-molecule photosensitizers

UR - https://www.scopus.com/pages/publications/85102128562

U2 - 10.1016/j.jphotobiol.2021.112171

DO - 10.1016/j.jphotobiol.2021.112171

M3 - Article

C2 - 33711563

AN - SCOPUS:85102128562

SN - 1011-1344

VL - 217

JO - Journal of Photochemistry and Photobiology B: Biology

JF - Journal of Photochemistry and Photobiology B: Biology

M1 - 112171

ER -

Dual laser activatable brominated hemicyanine as a highly efficient and photostable multimodal phototherapy agent

Özet

Bibliyografik not

Finansman

BM SKH

Belgeye Erişim

Diğer Dosyalar ve Linkler

Parmak izi

Alıntı Yap