Double click reaction strategies for polymer conjugation and post-functionalization of polymers

Double click reaction strategies, which are a combination of different type of click reactions, allow the preparation of polymers with various topologies and the post-functionalization of polymers, which cannot be easily achieved by using only one click reaction. The most studied click reaction combinations may be listed as the Cu(i) catalyzed azide-alkyne cycloaddition (CuAAC)-Diels-Alder, and the CuAAC-nitroxide radical coupling reactions for polymer-polymer conjugation and the CuAAC-Diels-Alder, or the CuAAC-thiol-ene reactions for post-modification of polymers.