Differential Pulse Voltammetric Determination of Montelukast in Tablets and Human Plasma by Using Chitosan Modified Carbon Paste Electrode

Electrochemical reduction and determination of montelukast (MKS) was studied in methanol - 0.1M HCl solution (1:1, v/v) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at chitosan modified carbon paste electrode. The linear range was 1.70×10^-7-1.83×10^-5M for DPV analysis. Limit of detection (LOD) and limit of quantification (LOQ) were 5.32×10^-8M and 1.61×10^-7M, respectively. The developed method was successfully applied to the determination of MKS in tablets and spiked human plasma. The results obtained were in good agreement with those obtained using a reported spectrofluorimetric technique.