Differential Pulse Voltammetric Determination of Montelukast in Tablets and Human Plasma by Using Chitosan Modified Carbon Paste Electrode

Gülcemal Yildiz; Zeynep Aydoǧmuş; Jean Michel Kauffmann

doi:10.1002/elan.201300077

Differential Pulse Voltammetric Determination of Montelukast in Tablets and Human Plasma by Using Chitosan Modified Carbon Paste Electrode

Gülcemal Yildiz, Zeynep Aydoǧmuş^*, Jean Michel Kauffmann

^*Bu çalışma için yazışmadan sorumlu yazar

Kimya Bölümü

Araştırma sonucu: ???type-name??? › Makale › bilirkişi

16 Atıf (Scopus)

Özet

Electrochemical reduction and determination of montelukast (MKS) was studied in methanol - 0.1M HCl solution (1:1, v/v) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at chitosan modified carbon paste electrode. The linear range was 1.70×10^-7-1.83×10^-5M for DPV analysis. Limit of detection (LOD) and limit of quantification (LOQ) were 5.32×10^-8M and 1.61×10^-7M, respectively. The developed method was successfully applied to the determination of MKS in tablets and spiked human plasma. The results obtained were in good agreement with those obtained using a reported spectrofluorimetric technique.

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	1796-1802
Sayfa sayısı	7
Dergi	Electroanalysis
Hacim	25
Basın numarası	7
DOI'lar	https://doi.org/10.1002/elan.201300077
Yayın durumu	Yayınlandı - Tem 2013

Belgeye Erişim

10.1002/elan.201300077

Diğer Dosyalar ve Linkler

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Alıntı Yap

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title = "Differential Pulse Voltammetric Determination of Montelukast in Tablets and Human Plasma by Using Chitosan Modified Carbon Paste Electrode",

abstract = "Electrochemical reduction and determination of montelukast (MKS) was studied in methanol - 0.1M HCl solution (1:1, v/v) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at chitosan modified carbon paste electrode. The linear range was 1.70×10-7-1.83×10-5M for DPV analysis. Limit of detection (LOD) and limit of quantification (LOQ) were 5.32×10-8M and 1.61×10-7M, respectively. The developed method was successfully applied to the determination of MKS in tablets and spiked human plasma. The results obtained were in good agreement with those obtained using a reported spectrofluorimetric technique.",

keywords = "Chitosan modified carbon paste electrode, Drugs, Montelukast, Plasma, Voltammetry",

author = "G{\"u}lcemal Yildiz and Zeynep Aydoǧmu{\c s} and Kauffmann, {Jean Michel}",

year = "2013",

month = jul,

doi = "10.1002/elan.201300077",

language = "English",

volume = "25",

pages = "1796--1802",

journal = "Electroanalysis",

issn = "1040-0397",

publisher = "Wiley-VCH Verlag",

number = "7",

}

TY - JOUR

T1 - Differential Pulse Voltammetric Determination of Montelukast in Tablets and Human Plasma by Using Chitosan Modified Carbon Paste Electrode

AU - Yildiz, Gülcemal

AU - Aydoǧmuş, Zeynep

AU - Kauffmann, Jean Michel

PY - 2013/7

Y1 - 2013/7

N2 - Electrochemical reduction and determination of montelukast (MKS) was studied in methanol - 0.1M HCl solution (1:1, v/v) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at chitosan modified carbon paste electrode. The linear range was 1.70×10-7-1.83×10-5M for DPV analysis. Limit of detection (LOD) and limit of quantification (LOQ) were 5.32×10-8M and 1.61×10-7M, respectively. The developed method was successfully applied to the determination of MKS in tablets and spiked human plasma. The results obtained were in good agreement with those obtained using a reported spectrofluorimetric technique.

AB - Electrochemical reduction and determination of montelukast (MKS) was studied in methanol - 0.1M HCl solution (1:1, v/v) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at chitosan modified carbon paste electrode. The linear range was 1.70×10-7-1.83×10-5M for DPV analysis. Limit of detection (LOD) and limit of quantification (LOQ) were 5.32×10-8M and 1.61×10-7M, respectively. The developed method was successfully applied to the determination of MKS in tablets and spiked human plasma. The results obtained were in good agreement with those obtained using a reported spectrofluorimetric technique.

KW - Chitosan modified carbon paste electrode

KW - Drugs

KW - Montelukast

KW - Plasma

KW - Voltammetry

UR - http://www.scopus.com/inward/record.url?scp=84880365943&partnerID=8YFLogxK

U2 - 10.1002/elan.201300077

DO - 10.1002/elan.201300077

M3 - Article

AN - SCOPUS:84880365943

SN - 1040-0397

VL - 25

SP - 1796

EP - 1802

JO - Electroanalysis

JF - Electroanalysis

IS - 7

ER -

Differential Pulse Voltammetric Determination of Montelukast in Tablets and Human Plasma by Using Chitosan Modified Carbon Paste Electrode

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