Differential Pulse Voltammetric Determination of Anticancer Drug Regorafenib at a Carbon Paste Electrode: Electrochemical Study and Density Functional Theory Computations

Aydoğmuş Zeynep Aydoğmuş; Serap Saglik Aslan; Gülcemal Yildiz; Ahmet Senocak

doi:10.1134/S1061934820050032

Differential Pulse Voltammetric Determination of Anticancer Drug Regorafenib at a Carbon Paste Electrode: Electrochemical Study and Density Functional Theory Computations

Aydoğmuş Zeynep Aydoğmuş^*
, Serap Saglik Aslan
, Gülcemal Yildiz
, Ahmet Senocak

^*Bu çalışma için yazışmadan sorumlu yazar

Kimya Bölümü

Araştırma sonucu: Dergiye katkı › Makale › bilirkişi

12 Atıf (Scopus)

Özet

Abstract: Electrochemical properties of regorafenib (REG) were studied in 0.1 M Britton−Robinson buffer-methanol solutions (3 : 2, v/v) with pH between 3 and 8 at carbon paste electrode by cyclic and differential pulse voltammetry. The results exhibited irreversible anodic peak at about 0.90 V vs. Ag/AgCl, NaCl (3 M). The anodic peak was found to be diffusion–adsorption controlled. Mechanism of REG electrochemical reaction was studied by performing density functional theory computations and mass spectrometric analysis. A validated differential pulse voltammetry (DPV) technique for REG determination was performed. The calibration curve of REG on carbon paste electrode was linear in the concentration range of 0.5–13 μg/mL and limit of detection was 0.10 µg/mL. The recommended DPV method was used to detect REG in spiked plasma and urine specimens and average recoveries were 94%.

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	691-700
Sayfa sayısı	10
Dergi	Journal of Analytical Chemistry
Hacim	75
Basın numarası	5
DOI'lar	https://doi.org/10.1134/S1061934820050032
Yayın durumu	Yayınlandı - 1 May 2020

Bibliyografik not

Publisher Copyright:
© 2020, Pleiades Publishing, Ltd.

Finansman

This work was supported by Scientific Research Project Coordination Unit of Istanbul University, Project numbers: PYP-17194 and BEK-2017-25714. ACKNOWLEDGMENTS We wish to thank Bayer for supplying regorafenib and TUBITAK ULAKBIM, High Performance and Grid Computing Center (TR-Grid e-Infrastructure) for the calculations reported in the theoretical part of this paper. We also thank to U?ur BOZKAYA for using Gaussian 09 program package.

Finansörler	Finansör numarası
High Performance and Grid Computing Center
TUBITAK ULAKBIM
Bayer
Istanbul Üniversitesi	PYP-17194, BEK-2017-25714

BM SKH

Bu sonuç, aşağıdaki Sürdürülebilir Kalkınma Hedefine/Hedeflerine katkıda bulunur

SKH 3 Sağlık ve Kaliteli Yaşam

Belgeye Erişim

10.1134/S1061934820050032

Diğer Dosyalar ve Linkler

Link to publication in Scopus

Alıntı Yap

@article{a0880a9c305c44389fbf27e7d3fe7223,

title = "Differential Pulse Voltammetric Determination of Anticancer Drug Regorafenib at a Carbon Paste Electrode: Electrochemical Study and Density Functional Theory Computations",

abstract = "Abstract: Electrochemical properties of regorafenib (REG) were studied in 0.1 M Britton−Robinson buffer-methanol solutions (3 : 2, v/v) with pH between 3 and 8 at carbon paste electrode by cyclic and differential pulse voltammetry. The results exhibited irreversible anodic peak at about 0.90 V vs. Ag/AgCl, NaCl (3 M). The anodic peak was found to be diffusion–adsorption controlled. Mechanism of REG electrochemical reaction was studied by performing density functional theory computations and mass spectrometric analysis. A validated differential pulse voltammetry (DPV) technique for REG determination was performed. The calibration curve of REG on carbon paste electrode was linear in the concentration range of 0.5–13 μg/mL and limit of detection was 0.10 µg/mL. The recommended DPV method was used to detect REG in spiked plasma and urine specimens and average recoveries were 94\%.",

keywords = "density functional theory, determination, plasma, regorafenib, urine, voltammetry",

author = "\{Zeynep Aydoğmu{\c s}\}, Aydoğmu{\c s} and Aslan, \{Serap Saglik\} and G{\"u}lcemal Yildiz and Ahmet Senocak",

note = "Publisher Copyright: {\textcopyright} 2020, Pleiades Publishing, Ltd.",

year = "2020",

month = may,

day = "1",

doi = "10.1134/S1061934820050032",

language = "English",

volume = "75",

pages = "691--700",

journal = "Journal of Analytical Chemistry",

issn = "1061-9348",

publisher = "Pleiades Publishing",

number = "5",

}

Differential Pulse Voltammetric Determination of Anticancer Drug Regorafenib at a Carbon Paste Electrode: Electrochemical Study and Density Functional Theory Computations. / Zeynep Aydoğmuş, Aydoğmuş; Aslan, Serap Saglik; Yildiz, Gülcemal et al.
In: Journal of Analytical Chemistry, Hac. 75, No. 5, 01.05.2020, p. 691-700.

Araştırma sonucu: Dergiye katkı › Makale › bilirkişi

TY - JOUR

T1 - Differential Pulse Voltammetric Determination of Anticancer Drug Regorafenib at a Carbon Paste Electrode

T2 - Electrochemical Study and Density Functional Theory Computations

AU - Zeynep Aydoğmuş, Aydoğmuş

AU - Aslan, Serap Saglik

AU - Yildiz, Gülcemal

AU - Senocak, Ahmet

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Abstract: Electrochemical properties of regorafenib (REG) were studied in 0.1 M Britton−Robinson buffer-methanol solutions (3 : 2, v/v) with pH between 3 and 8 at carbon paste electrode by cyclic and differential pulse voltammetry. The results exhibited irreversible anodic peak at about 0.90 V vs. Ag/AgCl, NaCl (3 M). The anodic peak was found to be diffusion–adsorption controlled. Mechanism of REG electrochemical reaction was studied by performing density functional theory computations and mass spectrometric analysis. A validated differential pulse voltammetry (DPV) technique for REG determination was performed. The calibration curve of REG on carbon paste electrode was linear in the concentration range of 0.5–13 μg/mL and limit of detection was 0.10 µg/mL. The recommended DPV method was used to detect REG in spiked plasma and urine specimens and average recoveries were 94%.

AB - Abstract: Electrochemical properties of regorafenib (REG) were studied in 0.1 M Britton−Robinson buffer-methanol solutions (3 : 2, v/v) with pH between 3 and 8 at carbon paste electrode by cyclic and differential pulse voltammetry. The results exhibited irreversible anodic peak at about 0.90 V vs. Ag/AgCl, NaCl (3 M). The anodic peak was found to be diffusion–adsorption controlled. Mechanism of REG electrochemical reaction was studied by performing density functional theory computations and mass spectrometric analysis. A validated differential pulse voltammetry (DPV) technique for REG determination was performed. The calibration curve of REG on carbon paste electrode was linear in the concentration range of 0.5–13 μg/mL and limit of detection was 0.10 µg/mL. The recommended DPV method was used to detect REG in spiked plasma and urine specimens and average recoveries were 94%.

KW - density functional theory

KW - determination

KW - plasma

KW - regorafenib

KW - urine

KW - voltammetry

UR - https://www.scopus.com/pages/publications/85084186817

U2 - 10.1134/S1061934820050032

DO - 10.1134/S1061934820050032

M3 - Article

AN - SCOPUS:85084186817

SN - 1061-9348

VL - 75

SP - 691

EP - 700

JO - Journal of Analytical Chemistry

JF - Journal of Analytical Chemistry

IS - 5

ER -

Differential Pulse Voltammetric Determination of Anticancer Drug Regorafenib at a Carbon Paste Electrode: Electrochemical Study and Density Functional Theory Computations

Özet

Bibliyografik not

Finansman

BM SKH

Belgeye Erişim

Diğer Dosyalar ve Linkler

Parmak izi

Alıntı Yap