Differential Pulse Voltammetric Determination of Anticancer Drug Regorafenib at a Carbon Paste Electrode: Electrochemical Study and Density Functional Theory Computations

Aydoğmuş Zeynep Aydoğmuş*, Serap Saglik Aslan, Gülcemal Yildiz, Ahmet Senocak

*Bu çalışma için yazışmadan sorumlu yazar

Araştırma sonucu: Dergiye katkıMakalebilirkişi

10 Atıf (Scopus)

Özet

Abstract: Electrochemical properties of regorafenib (REG) were studied in 0.1 M Britton−Robinson buffer-methanol solutions (3 : 2, v/v) with pH between 3 and 8 at carbon paste electrode by cyclic and differential pulse voltammetry. The results exhibited irreversible anodic peak at about 0.90 V vs. Ag/AgCl, NaCl (3 M). The anodic peak was found to be diffusion–adsorption controlled. Mechanism of REG electrochemical reaction was studied by performing density functional theory computations and mass spectrometric analysis. A validated differential pulse voltammetry (DPV) technique for REG determination was performed. The calibration curve of REG on carbon paste electrode was linear in the concentration range of 0.5–13 μg/mL and limit of detection was 0.10 µg/mL. The recommended DPV method was used to detect REG in spiked plasma and urine specimens and average recoveries were 94%.

Orijinal dilİngilizce
Sayfa (başlangıç-bitiş)691-700
Sayfa sayısı10
DergiJournal of Analytical Chemistry
Hacim75
Basın numarası5
DOI'lar
Yayın durumuYayınlandı - 1 May 2020

Bibliyografik not

Publisher Copyright:
© 2020, Pleiades Publishing, Ltd.

Finansman

This work was supported by Scientific Research Project Coordination Unit of Istanbul University, Project numbers: PYP-17194 and BEK-2017-25714. ACKNOWLEDGMENTS We wish to thank Bayer for supplying regorafenib and TUBITAK ULAKBIM, High Performance and Grid Computing Center (TR-Grid e-Infrastructure) for the calculations reported in the theoretical part of this paper. We also thank to U?ur BOZKAYA for using Gaussian 09 program package.

FinansörlerFinansör numarası
High Performance and Grid Computing Center
TUBITAK ULAKBIM
Bayer
Istanbul ÜniversitesiPYP-17194, BEK-2017-25714

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