Development of Procaine Loaded Transdermal Patches Based on Biopolymer Pectin, Castor Oil, and Polyethylene Glycol for Controllable Drug Release Studies and Their Characterizations

Aybuke Tavasli*, Banu Kocaaga, F. Seniha Guner

*Bu çalışma için yazışmadan sorumlu yazar

Araştırma sonucu: ???type-name???Makalebilirkişi

Özet

Transdermal drug delivery systems have considerable attention in clinical and point-of-care applications due to their superior advantages such as non-invasive properties and keeping drug efficiency. To overcome the skin barrier, penetration enhancers are employed in the patch design. Chemical penetration enhancers are the most frequently applied way to improve drug diffusion through the barrier. Transdermal patches are designed as a drug-loaded thin-film hydrogel. Since the patch material must be biocompatible and eco-friendly, in this study, pectin-based transdermal patches are designed, and procaine, a painkiller drug is chosen as a model drug. Benzyl alcohol, polyethylene glycol, and castor oil are selected as chemical penetration enhancers. Drug diffusion experiments are carried out by using Franz diffusion cells at 37 °C. Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) are used to characterize the chemical structure and thermal properties of the patches. The patches are evaluated by the contact angle measurement and the swelling test in terms of their hydrophilicity and water uptake. Regarding in vitro drug release experiments by Franz diffusion cells, drug-loaded patches were examined (CxPy-PC; C-castor oil, P-PEG, x-y amounts (mg)). It is found that the most promising results come from C10-P5-PC (12.7 mg drug/g film) and C30-P5-PC (11.4 mg drug/ g film) which can be attributed to the synergetic and optimum amount of polyethylene glycol and castor oil.

Orijinal dilİngilizce
Makale numarasıe202301115
DergiChemistrySelect
Hacim8
Basın numarası34
DOI'lar
Yayın durumuYayınlandı - 13 Eyl 2023

Bibliyografik not

Publisher Copyright:
© 2023 Wiley-VCH GmbH.

Finansman

This research was supported by Scientific Research Projects (BAP) – ITU with project number MYL‐2018‐41820.

FinansörlerFinansör numarası
International Technological UniversityMYL‐2018‐41820

    Parmak izi

    Development of Procaine Loaded Transdermal Patches Based on Biopolymer Pectin, Castor Oil, and Polyethylene Glycol for Controllable Drug Release Studies and Their Characterizations' araştırma başlıklarına git. Birlikte benzersiz bir parmak izi oluştururlar.

    Alıntı Yap