Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy

Samira Savani; Kubra Onbasli; Hande Gunduz; Eda Aydındogan; Merve Erkısa; Abdullah Muti; Minahil Khan; Alphan Sennaroglu; Engin Ulukaya; Havva Yagci Acar; Safacan Kolemen

doi:10.1016/j.bioorg.2022.105725

Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy

Samira Savani, Kubra Onbasli, Hande Gunduz, Eda Aydındogan, Merve Erkısa, Abdullah Muti, Minahil Khan, Alphan Sennaroglu, Engin Ulukaya, Havva Yagci Acar^*, Safacan Kolemen

^*Bu çalışma için yazışmadan sorumlu yazar

Araştırma sonucu: Dergiye katkı › Makale › bilirkişi

9 Atıf (Scopus)

Özet

A cysteine (Cys) activatable chlorinated hemicyanine (Cl-Cys) was introduced as a tumour selective image-guided dual phototherapy agent. Cl-Cys exhibited a significant turn on response in its near-IR emission signal and activated its singlet oxygen generation as well as photothermal conversion potentials upon reacting with Cys. The laser irradiation of Cl-Cys induced significant cell death in cancer cells with high Cys level, while it stayed deactivated and non-emissive in a healthy cell line. A profound synergistic PDT/PTT effect was observed at high doses. Remarkably, Cl-Cys marks the first ever example of Cys-responsive small organic-based therapeutic agent and holds a great promise to develop new activity-based photosensitizers for dual phototherapy action.

Orijinal dil	İngilizce
Makale numarası	105725
Dergi	Bioorganic Chemistry
Hacim	122
DOI'lar	https://doi.org/10.1016/j.bioorg.2022.105725
Yayın durumu	Yayınlandı - May 2022
Harici olarak yayınlandı	Evet

Bibliyografik not

Publisher Copyright:
© 2022 Elsevier Inc.

Finansman

SK thanks BAGEP award of Science Academy for the financial support. Authors thank Kübra Nur Özvural Sertçelik for the graphical abstract.

Finansörler	Finansör numarası
Bilim Akademisi

BM SKH

Bu sonuç, aşağıdaki Sürdürülebilir Kalkınma Hedefine/Hedeflerine katkıda bulunur

Belgeye Erişim

10.1016/j.bioorg.2022.105725

Diğer Dosyalar ve Linkler

Link to publication in Scopus

Alıntı Yap

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title = "Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy",

abstract = "A cysteine (Cys) activatable chlorinated hemicyanine (Cl-Cys) was introduced as a tumour selective image-guided dual phototherapy agent. Cl-Cys exhibited a significant turn on response in its near-IR emission signal and activated its singlet oxygen generation as well as photothermal conversion potentials upon reacting with Cys. The laser irradiation of Cl-Cys induced significant cell death in cancer cells with high Cys level, while it stayed deactivated and non-emissive in a healthy cell line. A profound synergistic PDT/PTT effect was observed at high doses. Remarkably, Cl-Cys marks the first ever example of Cys-responsive small organic-based therapeutic agent and holds a great promise to develop new activity-based photosensitizers for dual phototherapy action.",

keywords = "Cancer, Cysteine, Hemicyanine, Photosensitizers, Phototherapy, Theranostics",

author = "Samira Savani and Kubra Onbasli and Hande Gunduz and Eda Aydındogan and Merve Erkısa and Abdullah Muti and Minahil Khan and Alphan Sennaroglu and Engin Ulukaya and {Yagci Acar}, Havva and Safacan Kolemen",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

month = may,

doi = "10.1016/j.bioorg.2022.105725",

language = "English",

volume = "122",

journal = "Bioorganic Chemistry",

issn = "0045-2068",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy

AU - Savani, Samira

AU - Onbasli, Kubra

AU - Gunduz, Hande

AU - Aydındogan, Eda

AU - Erkısa, Merve

AU - Muti, Abdullah

AU - Khan, Minahil

AU - Sennaroglu, Alphan

AU - Ulukaya, Engin

AU - Yagci Acar, Havva

AU - Kolemen, Safacan

PY - 2022/5

Y1 - 2022/5

N2 - A cysteine (Cys) activatable chlorinated hemicyanine (Cl-Cys) was introduced as a tumour selective image-guided dual phototherapy agent. Cl-Cys exhibited a significant turn on response in its near-IR emission signal and activated its singlet oxygen generation as well as photothermal conversion potentials upon reacting with Cys. The laser irradiation of Cl-Cys induced significant cell death in cancer cells with high Cys level, while it stayed deactivated and non-emissive in a healthy cell line. A profound synergistic PDT/PTT effect was observed at high doses. Remarkably, Cl-Cys marks the first ever example of Cys-responsive small organic-based therapeutic agent and holds a great promise to develop new activity-based photosensitizers for dual phototherapy action.

AB - A cysteine (Cys) activatable chlorinated hemicyanine (Cl-Cys) was introduced as a tumour selective image-guided dual phototherapy agent. Cl-Cys exhibited a significant turn on response in its near-IR emission signal and activated its singlet oxygen generation as well as photothermal conversion potentials upon reacting with Cys. The laser irradiation of Cl-Cys induced significant cell death in cancer cells with high Cys level, while it stayed deactivated and non-emissive in a healthy cell line. A profound synergistic PDT/PTT effect was observed at high doses. Remarkably, Cl-Cys marks the first ever example of Cys-responsive small organic-based therapeutic agent and holds a great promise to develop new activity-based photosensitizers for dual phototherapy action.

KW - Cancer

KW - Cysteine

KW - Hemicyanine

KW - Photosensitizers

KW - Phototherapy

KW - Theranostics

UR - http://www.scopus.com/inward/record.url?scp=85126525592&partnerID=8YFLogxK

U2 - 10.1016/j.bioorg.2022.105725

DO - 10.1016/j.bioorg.2022.105725

M3 - Article

C2 - 35316664

AN - SCOPUS:85126525592

SN - 0045-2068

VL - 122

JO - Bioorganic Chemistry

JF - Bioorganic Chemistry

M1 - 105725

ER -

Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy

Özet

Bibliyografik not

Finansman

BM SKH

Belgeye Erişim

Diğer Dosyalar ve Linkler

Parmak izi

Alıntı Yap