Determination of alginate copolymer in pharmaceutical formulations by micellar electrokinetic chromatography

Nevin Öztekin; Selda Başkan; F. Bedia Erim

doi:10.1016/j.jchromb.2006.12.025

Determination of alginate copolymer in pharmaceutical formulations by micellar electrokinetic chromatography

Nevin Öztekin, Selda Başkan, F. Bedia Erim^*

^*Bu çalışma için yazışmadan sorumlu yazar

Kimya Bölümü

Istanbul Technical University

Araştırma sonucu: ???type-name??? › Makale › bilirkişi

12 Atıf (Scopus)

Özet

A micellar electrokinetic chromatography method was developed for the determination and quantification of sodium alginate. The alginate peak migrated in the very short time of 1.33 min and calibrated easily though the polydisperse properties of alginates. The minimum detection limit (LOD) of the method was calculated as 0.393 mg/ml. This analysis method was successfully applied to the alginate quantification in an antacid pharmaceutical formulation. Precise and reproducible analysis results were obtained, with liquid formulations injected directly without any pre-separation process.

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	488-492
Sayfa sayısı	5
Dergi	Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Hacim	850
Basın numarası	1-2
DOI'lar	https://doi.org/10.1016/j.jchromb.2006.12.025
Yayın durumu	Yayınlandı - 1 May 2007

Belgeye Erişim

10.1016/j.jchromb.2006.12.025

Diğer Dosyalar ve Linkler

Link to publication in Scopus

Alıntı Yap

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title = "Determination of alginate copolymer in pharmaceutical formulations by micellar electrokinetic chromatography",

abstract = "A micellar electrokinetic chromatography method was developed for the determination and quantification of sodium alginate. The alginate peak migrated in the very short time of 1.33 min and calibrated easily though the polydisperse properties of alginates. The minimum detection limit (LOD) of the method was calculated as 0.393 mg/ml. This analysis method was successfully applied to the alginate quantification in an antacid pharmaceutical formulation. Precise and reproducible analysis results were obtained, with liquid formulations injected directly without any pre-separation process.",

keywords = "Alginate, Antacid, Capillary electrophoresis, MEKC",

author = "Nevin {\"O}ztekin and Selda Ba{\c s}kan and Erim, {F. Bedia}",

year = "2007",

month = may,

day = "1",

doi = "10.1016/j.jchromb.2006.12.025",

language = "English",

volume = "850",

pages = "488--492",

journal = "Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences",

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TY - JOUR

T1 - Determination of alginate copolymer in pharmaceutical formulations by micellar electrokinetic chromatography

AU - Öztekin, Nevin

AU - Başkan, Selda

AU - Erim, F. Bedia

PY - 2007/5/1

Y1 - 2007/5/1

N2 - A micellar electrokinetic chromatography method was developed for the determination and quantification of sodium alginate. The alginate peak migrated in the very short time of 1.33 min and calibrated easily though the polydisperse properties of alginates. The minimum detection limit (LOD) of the method was calculated as 0.393 mg/ml. This analysis method was successfully applied to the alginate quantification in an antacid pharmaceutical formulation. Precise and reproducible analysis results were obtained, with liquid formulations injected directly without any pre-separation process.

AB - A micellar electrokinetic chromatography method was developed for the determination and quantification of sodium alginate. The alginate peak migrated in the very short time of 1.33 min and calibrated easily though the polydisperse properties of alginates. The minimum detection limit (LOD) of the method was calculated as 0.393 mg/ml. This analysis method was successfully applied to the alginate quantification in an antacid pharmaceutical formulation. Precise and reproducible analysis results were obtained, with liquid formulations injected directly without any pre-separation process.

KW - Alginate

KW - Antacid

KW - Capillary electrophoresis

KW - MEKC

UR - http://www.scopus.com/inward/record.url?scp=34247180700&partnerID=8YFLogxK

U2 - 10.1016/j.jchromb.2006.12.025

DO - 10.1016/j.jchromb.2006.12.025

M3 - Article

C2 - 17224310

AN - SCOPUS:34247180700

SN - 1570-0232

VL - 850

SP - 488

EP - 492

JO - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

JF - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

IS - 1-2

ER -

Determination of alginate copolymer in pharmaceutical formulations by micellar electrokinetic chromatography

Özet

Belgeye Erişim

Diğer Dosyalar ve Linkler

Parmak izi

Alıntı Yap