Control of innate and adaptive immunity by the inflammasome

Ceren Ciraci; John R. Janczy; Fayyaz S. Sutterwala; Suzanne L. Cassel

doi:10.1016/j.micinf.2012.07.007

Control of innate and adaptive immunity by the inflammasome

Ceren Ciraci
, John R. Janczy
, Fayyaz S. Sutterwala
, Suzanne L. Cassel^*

^*Bu çalışma için yazışmadan sorumlu yazar

University of Iowa
Department of Veterans Affairs

Araştırma sonucu: Dergiye katkı › Makale › bilirkişi

66 Atıf (Scopus)

Özet

The importance of innate immunity lies not only in directly confronting pathogenic and non-pathogenic insults but also in instructing the development of an efficient adaptive immune response. The Nlrp3 inflammasome provides a platform for the activation of caspase-1 with the subsequent processing and secretion of IL-1 family members. Given the importance of IL-1 in a variety of inflammatory diseases, understanding the role of the Nlrp3 inflammasome in the initiation of innate and adaptive immune responses cannot be overstated. This review examines recent advances in inflammasome biology with an emphasis on its roles in sterile inflammation and triggering of adaptive immune responses.

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	1263-1270
Sayfa sayısı	8
Dergi	Microbes and Infection
Hacim	14
Basın numarası	14
DOI'lar	https://doi.org/10.1016/j.micinf.2012.07.007
Yayın durumu	Yayınlandı - Kas 2012
Harici olarak yayınlandı	Evet

Finansman

NIH grants R01 AI087630 (F.S.S.), K08 AI067736 (S.L.C.), T32 AI007485 (J.R.J.), an Edward Mallinckrodt, Jr. Foundation scholarship (F.S.S.), a Merit Review Grant from the Veterans Administration IBX000167A (F.S.S.) and an Asthma and Allergy Foundation of America fellowship (S.L.C.) supported this work. The Inflammation Program is supported by resources and use of facilities at the Veterans Affairs Medical Center, Iowa City, IA. The authors have no conflicting financial interests.

Finansörler	Finansör numarası
Veterans Administration IBX000167A
National Institutes of Health	K08 AI067736, T32 AI007485
National Institute of Allergy and Infectious Diseases	R01AI087630
Asthma and Allergy Foundation of America

Belgeye Erişim

10.1016/j.micinf.2012.07.007

Diğer Dosyalar ve Linkler

Link to publication in Scopus

Alıntı Yap

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title = "Control of innate and adaptive immunity by the inflammasome",

abstract = "The importance of innate immunity lies not only in directly confronting pathogenic and non-pathogenic insults but also in instructing the development of an efficient adaptive immune response. The Nlrp3 inflammasome provides a platform for the activation of caspase-1 with the subsequent processing and secretion of IL-1 family members. Given the importance of IL-1 in a variety of inflammatory diseases, understanding the role of the Nlrp3 inflammasome in the initiation of innate and adaptive immune responses cannot be overstated. This review examines recent advances in inflammasome biology with an emphasis on its roles in sterile inflammation and triggering of adaptive immune responses.",

keywords = "Adaptive immunity, Inflammasome, Innate immunity",

author = "Ceren Ciraci and Janczy, \{John R.\} and Sutterwala, \{Fayyaz S.\} and Cassel, \{Suzanne L.\}",

year = "2012",

month = nov,

doi = "10.1016/j.micinf.2012.07.007",

language = "English",

volume = "14",

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AU - Ciraci, Ceren

AU - Janczy, John R.

AU - Sutterwala, Fayyaz S.

AU - Cassel, Suzanne L.

PY - 2012/11

Y1 - 2012/11

N2 - The importance of innate immunity lies not only in directly confronting pathogenic and non-pathogenic insults but also in instructing the development of an efficient adaptive immune response. The Nlrp3 inflammasome provides a platform for the activation of caspase-1 with the subsequent processing and secretion of IL-1 family members. Given the importance of IL-1 in a variety of inflammatory diseases, understanding the role of the Nlrp3 inflammasome in the initiation of innate and adaptive immune responses cannot be overstated. This review examines recent advances in inflammasome biology with an emphasis on its roles in sterile inflammation and triggering of adaptive immune responses.

AB - The importance of innate immunity lies not only in directly confronting pathogenic and non-pathogenic insults but also in instructing the development of an efficient adaptive immune response. The Nlrp3 inflammasome provides a platform for the activation of caspase-1 with the subsequent processing and secretion of IL-1 family members. Given the importance of IL-1 in a variety of inflammatory diseases, understanding the role of the Nlrp3 inflammasome in the initiation of innate and adaptive immune responses cannot be overstated. This review examines recent advances in inflammasome biology with an emphasis on its roles in sterile inflammation and triggering of adaptive immune responses.

KW - Adaptive immunity

KW - Inflammasome

KW - Innate immunity

UR - https://www.scopus.com/pages/publications/84870292233

U2 - 10.1016/j.micinf.2012.07.007

DO - 10.1016/j.micinf.2012.07.007

M3 - Article

C2 - 22841804

AN - SCOPUS:84870292233

SN - 1286-4579

VL - 14

SP - 1263

EP - 1270

JO - Microbes and Infection

JF - Microbes and Infection

IS - 14

ER -

Control of innate and adaptive immunity by the inflammasome

Özet

Finansman

Belgeye Erişim

Diğer Dosyalar ve Linkler

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