Computational fluid dynamics modeling of momentum transport in rotating wall perfused bioreactor for cartilage tissue engineering

Mahmut N. Cinbiz, R. Seda Tiǧli, Işil Gerçek Beşkardeş, Menemşe Gümüşderelioglu*, Üner Çolak

*Bu çalışma için yazışmadan sorumlu yazar

Araştırma sonucu: Dergiye katkıMakalebilirkişi

29 Atıf (Scopus)

Özet

In this study, computational fluid dynamics (CFD) analysis of a rotating-wall perfused-vessel (RWPV) bioreactor is performed to characterize the complex hydrodynamic environment for the simulation of cartilage development in RWPV bioreactor in the presence of tissue-engineered cartilage constructs, i.e., cell-chitosan scaffolds. Shear stress exerted on chitosan scaffolds in bioreactor was calculated for different rotational velocities in the range of 33-38rpm. According to the calculations, the lateral and lower surfaces were exposed to 0.07926-0.11069dyne/cm2 and 0.05974-0.08345dyne/cm2, respectively, while upper surfaces of constructs were exposed to 0.09196-0.12847dyne/cm2. Results validate adequate hydrodynamic environment for scaffolds in RWPV bioreactor for cartilage tissue development which concludes the suitability of operational conditions of RWPV bioreactor.

Orijinal dilİngilizce
Sayfa (başlangıç-bitiş)389-395
Sayfa sayısı7
DergiJournal of Biotechnology
Hacim150
Basın numarası3
DOI'lar
Yayın durumuYayınlandı - Kas 2010
Harici olarak yayınlandıEvet

Finansman

This study was financially supported by Turkish Scientific and Research Council (Tübitak), Project No. 105M097.

FinansörlerFinansör numarası
Turkish Scientific and Research Council105M097

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