Özet
In this study, computational fluid dynamics (CFD) analysis of a rotating-wall perfused-vessel (RWPV) bioreactor is performed to characterize the complex hydrodynamic environment for the simulation of cartilage development in RWPV bioreactor in the presence of tissue-engineered cartilage constructs, i.e., cell-chitosan scaffolds. Shear stress exerted on chitosan scaffolds in bioreactor was calculated for different rotational velocities in the range of 33-38rpm. According to the calculations, the lateral and lower surfaces were exposed to 0.07926-0.11069dyne/cm2 and 0.05974-0.08345dyne/cm2, respectively, while upper surfaces of constructs were exposed to 0.09196-0.12847dyne/cm2. Results validate adequate hydrodynamic environment for scaffolds in RWPV bioreactor for cartilage tissue development which concludes the suitability of operational conditions of RWPV bioreactor.
Orijinal dil | İngilizce |
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Sayfa (başlangıç-bitiş) | 389-395 |
Sayfa sayısı | 7 |
Dergi | Journal of Biotechnology |
Hacim | 150 |
Basın numarası | 3 |
DOI'lar | |
Yayın durumu | Yayınlandı - Kas 2010 |
Harici olarak yayınlandı | Evet |
Finansman
This study was financially supported by Turkish Scientific and Research Council (Tübitak), Project No. 105M097.
Finansörler | Finansör numarası |
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Turkish Scientific and Research Council | 105M097 |