Comparison of ionic polymers in the targeted drug delivery applications as the coating materials on the Fe3O4 nanoparticles

Maide Gökçe Bekaroğlu, Ayşe Alemdar, Sevim İşçi*

*Bu çalışma için yazışmadan sorumlu yazar

Araştırma sonucu: ???type-name???Makalebilirkişi

19 Atıf (Scopus)

Özet

The objective of the study was to obtain multifunctional core shell nanostructures of superparamagnetic iron oxide nanoparticles (Fe3O4) coated with various ionic biopolymers that can optimize toxicity to healthy cells, colloidal instabilities and drug loading capacities. These nanostructures can also allow drug delivery to tumor tissue because of their magnetic properties, accumulation and drug release at tumor site could be controlled by means of an external magnetic field. The impact of the biopolymers with different ionic properties to final core shell structures were investigated and compared in terms of their colloidal properties, cytotoxicities, drug adsorption and drug delivery capacities. Besides, the effect of the surface charges on the healthy cells and cancer cells is very important factor affecting toxicity and drug delivery. The results showed that the drug delivery agents coated with cationic biopolymers with cationic surface properties significantly reduced cancer cell viability compared to the anionic and nonionic polymer coatings even though their drug loading capacities were found to be the lowest.

Orijinal dilİngilizce
Makale numarası109838
DergiMaterials Science and Engineering C
Hacim103
DOI'lar
Yayın durumuYayınlandı - Eki 2019

Bibliyografik not

Publisher Copyright:
© 2019

Finansman

This paper is supported by Research Fund of Turkey, TUBITAK ( 214M595 ) and Istanbul Technical University Research Fund ( 40842 ). We would like to thank to Assoc. Prof. Dr. Fatma Neşe Kök providing in-Vitro evaluation studies in their laboratories.

FinansörlerFinansör numarası
Istanbul Technical University Research Fund40842
Research Fund of Turkey
TUBITAK214M595

    Parmak izi

    Comparison of ionic polymers in the targeted drug delivery applications as the coating materials on the Fe3O4 nanoparticles' araştırma başlıklarına git. Birlikte benzersiz bir parmak izi oluştururlar.

    Alıntı Yap