Coarse-graining the nano-machine ribosome to elucidate its functional dynamics

Ozge Kurkcuoglu, Pemra Doruker*

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Özet

Coarse-grained computational techniques can provide information on conformational dynamics of the supramolecule ribosome, for which full-atom approaches become computationally demanding. Elastic network models and coarse-grained molecular dynamics simulations are the most commonly used methods for simple descriptions of the biomolecular structure. Usually, an amino acid or a nucleotide residue is represented by a single node, and simplified potential energy functions are used for interacting nodes. These approaches have been successful in reproducing the micro-to-milliseconds dynamics information, such as the experimentally observed ratchet-like rotation of the ribosomal subunits. Furthermore, they have provided insights on the structure-dynamicsfunction relationship of the ribosomal complex. This review summarizes various coarsegraining approaches on the nano-machine and recent studies that focus on its different functional sites.

Orijinal dilİngilizce
Ana bilgisayar yayını başlığıRibosomes
Ana bilgisayar yayını alt yazısıMolecular Structure, Role in Biological Functions and Implications for Genetic Diseases
YayınlayanNova Science Publishers, Inc.
Sayfalar119-132
Sayfa sayısı14
ISBN (Basılı)9781624176982
Yayın durumuYayınlandı - Mar 2013

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