TY - JOUR
T1 - Chemical Composition, Biological Activity, and Health-Promoting Effects of Withania somnifera for Pharma-Food Industry Applications
AU - Sharifi-Rad, Javad
AU - Quispe, Cristina
AU - Ayatollahi, Seyed Abdulmajid
AU - Kobarfard, Farzad
AU - Staniak, Mariola
AU - Stȩpień, Anna
AU - Czopek, Katarzyna
AU - Sen, Surjit
AU - Acharya, Krishnendu
AU - Matthews, Karl R.
AU - Sener, Bilge
AU - Devkota, Hari Prasad
AU - Kirkin, Celale
AU - Özçelik, Beraat
AU - Victoriano, Montserrat
AU - Martorell, Miquel
AU - Rasul Suleria, Hafiz Ansar
AU - Alshehri, Mohammed M.
AU - Chandran, Deepak
AU - Kumar, Manoj
AU - Cruz-Martins, Natália
AU - Cho, William C.
N1 - Publisher Copyright:
© 2021 Javad Sharifi-Rad et al.
PY - 2021
Y1 - 2021
N2 - The Withania genus comes from the Solanaceae family and includes around 23 species, spread over some areas of the Mediterranean, Asia, and East Africa. Widely used in traditional medicine for thousands of years, these plants are rich in secondary metabolites, with special emphasis on steroidal lactones, named withanolides which are used as ingredients in numerous formulations for a plethora of diseases, such as asthma, diabetes, arthritis, impotence, amnesia, hypertension, anxiety, stress, cancer, neurodegenerative, and cardiovascular diseases, and many others. Among them, Withania somnifera (L.) Dunal is the most widely addressed species from a pharmacological and agroindustrial point of view. In this sense, this review provides an overview of the folk uses, phytochemical composition, and biological activity, such as antioxidant, antimicrobial, anti-inflammatory, and cytotoxic activity of W. somnifera, although more recently other species have also been increasingly investigated. In addition, their health-promoting effects, i.e., antistress, anxiolytic, adaptogenic, antirheumatoid arthritis, chemoprotective, and cardiorespiratory-enhancing abilities, along with safety and adverse effects are also discussed.
AB - The Withania genus comes from the Solanaceae family and includes around 23 species, spread over some areas of the Mediterranean, Asia, and East Africa. Widely used in traditional medicine for thousands of years, these plants are rich in secondary metabolites, with special emphasis on steroidal lactones, named withanolides which are used as ingredients in numerous formulations for a plethora of diseases, such as asthma, diabetes, arthritis, impotence, amnesia, hypertension, anxiety, stress, cancer, neurodegenerative, and cardiovascular diseases, and many others. Among them, Withania somnifera (L.) Dunal is the most widely addressed species from a pharmacological and agroindustrial point of view. In this sense, this review provides an overview of the folk uses, phytochemical composition, and biological activity, such as antioxidant, antimicrobial, anti-inflammatory, and cytotoxic activity of W. somnifera, although more recently other species have also been increasingly investigated. In addition, their health-promoting effects, i.e., antistress, anxiolytic, adaptogenic, antirheumatoid arthritis, chemoprotective, and cardiorespiratory-enhancing abilities, along with safety and adverse effects are also discussed.
UR - http://www.scopus.com/inward/record.url?scp=85123263918&partnerID=8YFLogxK
U2 - 10.1155/2021/8985179
DO - 10.1155/2021/8985179
M3 - Review article
AN - SCOPUS:85123263918
SN - 0146-9428
VL - 2021
JO - Journal of Food Quality
JF - Journal of Food Quality
M1 - 8985179
ER -
