Characterization and comparative evaluation of polysulfone and polypropylene hollow fiber membranes for blood oxygenators

Oğuz Orhun Teber, Ayşegül Derya Altinay, Seyed Ali Naziri Mehrabani, Bihter Zeytuncu, Esra Ateş-Genceli, Ebru Dulekgurgen, Tansu Gölcez, Yahya Yıldız, Kerem Pekkan, İsmail Koyuncu*

*Bu çalışma için yazışmadan sorumlu yazar

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Özet

Blood oxygenators are used to saturate oxygen levels and remove carbon dioxide from the body during cardiopulmonary bypass. Although the natural lung is hydrophilic, commercially used oxygenator materials are hydrophobic. Surface hydrophobicity weakens blood compatibility, as long-term contact with the blood environment may lead to different degrees of blood activity. Polysulfone may be considered an alternative hydrophilic material in the design of oxygenators. Therefore, it may be directed toward developing hydrophilic membranes. This study aims to investigate the feasibility of achieving blood gas transfer with a polysulfone-based microporous hollow fiber membrane and compare it with the commercially available polypropylene membranes. Structural differences in the membrane morphology, surface hydrophilicity, tortuosity, mass transfer rate, and material properties under different operation conditions of temperature and flow rates are reported. The polysulfone membrane has a water contact angle of 81.3°, whereas a commercial polypropylene membrane is 94.5°. The mass transfer resistances (s/m) for the polysulfone and polypropylene membranes are calculated to be 4.8 × 104 and 1.5 × 104 at 25°C, respectively. The module made of polysulfone was placed in the cardiopulmonary bypass circuit in parallel with the commercial oxygenator, and pH, pO2, pCO2 levels, and metabolic activity were measured in blood samples.

Orijinal dilİngilizce
Makale numarasıe55121
DergiJournal of Applied Polymer Science
Hacim141
Basın numarası12
DOI'lar
Yayın durumuYayınlandı - 20 Mar 2024

Bibliyografik not

Publisher Copyright:
© 2024 The Authors. Journal of Applied Polymer Science published by Wiley Periodicals LLC.

Finansman

This study is supported by TÜBİTAK (The Scientific and Technological Research Council of Turkey) 118S108 (118S109) and European Research Council ERC-PoC 966765 Grants. This study is supported by TÜBİTAK (The Scientific and Technological Research Council of Turkey) 118S108 (118S109) and European Research Council ERC‐PoC 966765 Grants.

FinansörlerFinansör numarası
European Research Council ERC-PoC
European Research Council966765
Türkiye Bilimsel ve Teknolojik Araştırma Kurumu118S108, 118S109

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