Bismuth nitrate-promoted disproportionative condensation of indoles with cyclohexanone: A new-type azafulvenium reactivity of indole

H. Kilic, S. Bayindir, E. Erdogan, S. Agopcan Cinar, F. A.S. Konuklar, S. K. Bali, N. Saracoglu*, V. Aviyente

*Bu çalışma için yazışmadan sorumlu yazar

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8 Atıf (Scopus)

Özet

The indole nucleus is a privileged heterocyclic scaffold, which is present in several natural and synthetic compounds. New synthetic strategies to access functionalized indoles have therefore attracted the attention of both synthetic and medicinal chemists over the decades. In this study, the bismuth nitrate-promoted disproportionative condensation of indoles with cyclohexanone in one pot, to yield C3-cyclohexyl substituted indoles and 1,3-di(1H-indol-3-yl)benzene derivatives is reported for the first time. Using 3-methylindole with cyclopentanone, cyclohexanone, and cycloheptanone results in new and different synthetic pathways. The plausible reaction mechanisms are presented and supported with DFT (M06-2X/6-31+G(d,p)) calculations.

Orijinal dilİngilizce
Sayfa (başlangıç-bitiş)9674-9687
Sayfa sayısı14
DergiNew Journal of Chemistry
Hacim41
Basın numarası18
DOI'lar
Yayın durumuYayınlandı - 2017

Bibliyografik not

Publisher Copyright:
© 2017 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.

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