Application of dempster-schafer method in family-based association studies

Farid Rajabli, Unal Goktas, Gul Inan

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Özet

In experiments designed for family-based association studies, methods such as transmission disequilibrium test require large number of trios to identify single-nucleotide polymorphisms associated with the disease. However, unavailability of a large number of trios is the Achilles' heel of many complex diseases, especially for late-onset diseases. In this paper, we propose a novel approach to this problem by means of the Dempster-Shafer method. The simulation studies show that the Dempster-Shafer method has a promising overall performance, in identifying single-nucleotide polymorphisms in the correct association class, as it has 90 percent accuracy even with 60 trios.

Orijinal dilİngilizce
Makale numarası6570482
Sayfa (başlangıç-bitiş)1071-1075
Sayfa sayısı5
DergiIEEE/ACM Transactions on Computational Biology and Bioinformatics
Hacim10
Basın numarası4
DOI'lar
Yayın durumuYayınlandı - Tem 2013
Harici olarak yayınlandıEvet

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