Anodic voltammetric behavior and determination of cefixime in pharmaceutical dosage forms and biological fluids

Ayşegul Golcu, Burcu Dogan, Sibel A. Ozkan*

*Bu çalışma için yazışmadan sorumlu yazar

Araştırma sonucu: ???type-name???Makalebilirkişi

85 Atıf (Scopus)

Özet

The voltammetric behavior of cefixime was studied using cyclic, linear sweep, differential pulse and square wave voltammetric techniques. The oxidation of cefixime was irreversible and exhibited diffusion controlled process depending on pH. The oxidation mechanism was proposed and discussed. Different parameters were tested to optimize the conditions for the determination of cefixime. The dependence of current intensities and potentials on pH, concentration, scan rate, nature of the buffer was investigated. According to the linear relationship between the peak current and the concentration, differential pulse (DPV) and square wave (SWV) voltammetric methods for cefixime assay in pharmaceutical dosage forms and biological fluids were developed. For the determination of cefixime were proposed in acetate buffer at pH 4.5, which allows quantitation over the 6 × 10-6-2 × 10-4 M range in supporting electrolyte and spiked serum sample; 8 × 10 -6-2 × 10-4 M range in urine sample; 6 × 10-6-1 × 10-4 M range in breast milk samples for both techniques. The repeatability, reproducibility, precision and accuracy of the methods in all media were investigated. No electroactive interferences from the excipients and endogenous substances were found in the pharmaceutical dosage forms and in the biological samples, respectively.

Orijinal dilİngilizce
Sayfa (başlangıç-bitiş)703-712
Sayfa sayısı10
DergiTalanta
Hacim67
Basın numarası4
DOI'lar
Yayın durumuYayınlandı - 15 Eki 2005
Harici olarak yayınlandıEvet

Finansman

The authors gratefully acknowledge Eczacıbası Pharm. Ind. for supplying cefixime standard sample and its pharmaceutical dosage forms. This work was realized the BAS 100W equipment which is supplied from Ankara University Scientific Research Foundation Project (Grant No: 20030803037).

FinansörlerFinansör numarası
Ankara University Scientific Research Foundation Project20030803037

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